Synthesis and evaluation of biological and nonlinear optical properties of some novel 2,4-disubstituted [1,3]-thiazoles carrying 2-(aryloxymethyl)-phenyl moiety

Channamata Shankar Naveena, Boja Poojary, Thangavelu Arulmoli, Kumshi Manjunatha, Ashwatanarayana Prabhu, Nalilu Sucheta Kumari

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A series of 2,4-disubstituted-[1,3]-thiazoles (4a-p and 6a-l) was synthesized from 2-(aryloxymethyl)benzoic acids (1a-d) through a multistep reaction sequence in good yield. The structures of the new compounds were established on the basis of their elemental analyses, IR, 1H-NMR, 13C-NMR and mass spectral data. All the synthesized compounds were screened for their antimicrobial and anti-inflammatory activities. Preliminary results indicated that some of them exhibit promising activities and they deserve more consideration as potential antimicrobial and anti-inflammatory agents. The nonlinear optical (NLO) property of 4a-p was also studied. The compound 4n with 2-(3-methylphenoxymethyl)phenyl and 4-nitrophenyl substituents showed very good NLO property compared to other compounds and also the reference compound, urea.

Original languageEnglish
Pages (from-to)1925-1937
Number of pages13
JournalMedicinal Chemistry Research
Volume22
Issue number4
DOIs
Publication statusPublished - 01-04-2013

Fingerprint

Thiazoles
Anti-Inflammatory Agents
Optical properties
Nuclear magnetic resonance
Benzoates
Urea
4-nitrophenyl
Proton Magnetic Resonance Spectroscopy
Carbon-13 Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Naveena, Channamata Shankar ; Poojary, Boja ; Arulmoli, Thangavelu ; Manjunatha, Kumshi ; Prabhu, Ashwatanarayana ; Kumari, Nalilu Sucheta. / Synthesis and evaluation of biological and nonlinear optical properties of some novel 2,4-disubstituted [1,3]-thiazoles carrying 2-(aryloxymethyl)-phenyl moiety. In: Medicinal Chemistry Research. 2013 ; Vol. 22, No. 4. pp. 1925-1937.
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abstract = "A series of 2,4-disubstituted-[1,3]-thiazoles (4a-p and 6a-l) was synthesized from 2-(aryloxymethyl)benzoic acids (1a-d) through a multistep reaction sequence in good yield. The structures of the new compounds were established on the basis of their elemental analyses, IR, 1H-NMR, 13C-NMR and mass spectral data. All the synthesized compounds were screened for their antimicrobial and anti-inflammatory activities. Preliminary results indicated that some of them exhibit promising activities and they deserve more consideration as potential antimicrobial and anti-inflammatory agents. The nonlinear optical (NLO) property of 4a-p was also studied. The compound 4n with 2-(3-methylphenoxymethyl)phenyl and 4-nitrophenyl substituents showed very good NLO property compared to other compounds and also the reference compound, urea.",
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Synthesis and evaluation of biological and nonlinear optical properties of some novel 2,4-disubstituted [1,3]-thiazoles carrying 2-(aryloxymethyl)-phenyl moiety. / Naveena, Channamata Shankar; Poojary, Boja; Arulmoli, Thangavelu; Manjunatha, Kumshi; Prabhu, Ashwatanarayana; Kumari, Nalilu Sucheta.

In: Medicinal Chemistry Research, Vol. 22, No. 4, 01.04.2013, p. 1925-1937.

Research output: Contribution to journalArticle

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AU - Naveena, Channamata Shankar

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AU - Arulmoli, Thangavelu

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AU - Prabhu, Ashwatanarayana

AU - Kumari, Nalilu Sucheta

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