Synthesis and evaluation of some substituted 2-arylamino coumarinyl thiazoles as potential NSAIDs

K. N. Venugopala; B. S. Jayashree; Mahesh Attimarad

Synthesis and evaluation of some substituted 2-arylamino coumarinyl thiazoles as potential NSAIDs

K. N. Venugopala, B. S. Jayashree, Mahesh Attimarad

Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Substituted 2′-arylamino-4′-(3-coumarinyl) thiazoles (5a-j) and 2′-arylamino-4′-(6-bromo-3-coumarinyl) thiazoles (5k-v) were synthesized by the condensation of respective 3-bromoacetyl-coumarins with thiourea and substituted phenylthioureas. Finally the compounds were characterized by spectral data and screened for their analgesic and anti-inflammatory activities. Some of these compounds exhibited promising activity.

Original language	English
Pages (from-to)	872-876
Number of pages	5
Journal	Asian Journal of Chemistry
Volume	16
Issue number	2
Publication status	Published - 01-04-2004

All Science Journal Classification (ASJC) codes

Chemistry(all)

Cite this

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abstract = "Substituted 2′-arylamino-4′-(3-coumarinyl) thiazoles (5a-j) and 2′-arylamino-4′-(6-bromo-3-coumarinyl) thiazoles (5k-v) were synthesized by the condensation of respective 3-bromoacetyl-coumarins with thiourea and substituted phenylthioureas. Finally the compounds were characterized by spectral data and screened for their analgesic and anti-inflammatory activities. Some of these compounds exhibited promising activity.",

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AU - Venugopala, K. N.

AU - Jayashree, B. S.

AU - Attimarad, Mahesh

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N2 - Substituted 2′-arylamino-4′-(3-coumarinyl) thiazoles (5a-j) and 2′-arylamino-4′-(6-bromo-3-coumarinyl) thiazoles (5k-v) were synthesized by the condensation of respective 3-bromoacetyl-coumarins with thiourea and substituted phenylthioureas. Finally the compounds were characterized by spectral data and screened for their analgesic and anti-inflammatory activities. Some of these compounds exhibited promising activity.

AB - Substituted 2′-arylamino-4′-(3-coumarinyl) thiazoles (5a-j) and 2′-arylamino-4′-(6-bromo-3-coumarinyl) thiazoles (5k-v) were synthesized by the condensation of respective 3-bromoacetyl-coumarins with thiourea and substituted phenylthioureas. Finally the compounds were characterized by spectral data and screened for their analgesic and anti-inflammatory activities. Some of these compounds exhibited promising activity.

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ER -

Synthesis and evaluation of some substituted 2-arylamino coumarinyl thiazoles as potential NSAIDs

Abstract

All Science Journal Classification (ASJC) codes

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