Synthesis and evaluation of some substituted 2-arylamino coumarinyl thiazoles as potential NSAIDs

K. N. Venugopala, B. S. Jayashree, Mahesh Attimarad

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Substituted 2′-arylamino-4′-(3-coumarinyl) thiazoles (5a-j) and 2′-arylamino-4′-(6-bromo-3-coumarinyl) thiazoles (5k-v) were synthesized by the condensation of respective 3-bromoacetyl-coumarins with thiourea and substituted phenylthioureas. Finally the compounds were characterized by spectral data and screened for their analgesic and anti-inflammatory activities. Some of these compounds exhibited promising activity.

Original languageEnglish
Pages (from-to)872-876
Number of pages5
JournalAsian Journal of Chemistry
Volume16
Issue number2
Publication statusPublished - 01-04-2004

Fingerprint

Thiazoles
Non-Steroidal Anti-Inflammatory Agents
Phenylthiourea
Coumarins
Thiourea
Condensation

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

@article{401a6e3abaf74fbb938ea5dc96abccdd,
title = "Synthesis and evaluation of some substituted 2-arylamino coumarinyl thiazoles as potential NSAIDs",
abstract = "Substituted 2′-arylamino-4′-(3-coumarinyl) thiazoles (5a-j) and 2′-arylamino-4′-(6-bromo-3-coumarinyl) thiazoles (5k-v) were synthesized by the condensation of respective 3-bromoacetyl-coumarins with thiourea and substituted phenylthioureas. Finally the compounds were characterized by spectral data and screened for their analgesic and anti-inflammatory activities. Some of these compounds exhibited promising activity.",
author = "Venugopala, {K. N.} and Jayashree, {B. S.} and Mahesh Attimarad",
year = "2004",
month = "4",
day = "1",
language = "English",
volume = "16",
pages = "872--876",
journal = "Asian Journal of Chemistry",
issn = "0970-7077",
publisher = "Chemical Publishing Co.",
number = "2",

}

Synthesis and evaluation of some substituted 2-arylamino coumarinyl thiazoles as potential NSAIDs. / Venugopala, K. N.; Jayashree, B. S.; Attimarad, Mahesh.

In: Asian Journal of Chemistry, Vol. 16, No. 2, 01.04.2004, p. 872-876.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and evaluation of some substituted 2-arylamino coumarinyl thiazoles as potential NSAIDs

AU - Venugopala, K. N.

AU - Jayashree, B. S.

AU - Attimarad, Mahesh

PY - 2004/4/1

Y1 - 2004/4/1

N2 - Substituted 2′-arylamino-4′-(3-coumarinyl) thiazoles (5a-j) and 2′-arylamino-4′-(6-bromo-3-coumarinyl) thiazoles (5k-v) were synthesized by the condensation of respective 3-bromoacetyl-coumarins with thiourea and substituted phenylthioureas. Finally the compounds were characterized by spectral data and screened for their analgesic and anti-inflammatory activities. Some of these compounds exhibited promising activity.

AB - Substituted 2′-arylamino-4′-(3-coumarinyl) thiazoles (5a-j) and 2′-arylamino-4′-(6-bromo-3-coumarinyl) thiazoles (5k-v) were synthesized by the condensation of respective 3-bromoacetyl-coumarins with thiourea and substituted phenylthioureas. Finally the compounds were characterized by spectral data and screened for their analgesic and anti-inflammatory activities. Some of these compounds exhibited promising activity.

UR - http://www.scopus.com/inward/record.url?scp=4544250901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4544250901&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 872

EP - 876

JO - Asian Journal of Chemistry

JF - Asian Journal of Chemistry

SN - 0970-7077

IS - 2

ER -