Synthesis and evaluation of urea and thiourea derivatives of oxazolidinones as antibacterial agents

S.K.R. Aaramadaka, M.K. Guha, G. Prabhu, S.G. Kini, M. Vijayan

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Urea and thiourea derivatives of oxazolidinones were synthesized and their inhibitory activity (MIC) was determined on the bacterial strains which includes clinical isolates and quality control organisms. The structure activity relationships were studied and a 3D-QSAR model was built using Genetic Function Approximation. Interestingly found that electron withdrawing groups at the ortho position of the phenyl ring enhances the activity. © 2007 Pharmaceutical Society of Japan.
Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Issue number2
Publication statusPublished - 2007


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