Synthesis and evaluation of urea and thiourea derivatives of oxazolidinones as antibacterial agents

S.K.R. Aaramadaka, M.K. Guha, G. Prabhu, S.G. Kini, M. Vijayan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Urea and thiourea derivatives of oxazolidinones were synthesized and their inhibitory activity (MIC) was determined on the bacterial strains which includes clinical isolates and quality control organisms. The structure activity relationships were studied and a 3D-QSAR model was built using Genetic Function Approximation. Interestingly found that electron withdrawing groups at the ortho position of the phenyl ring enhances the activity. © 2007 Pharmaceutical Society of Japan.
Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number2
DOIs
Publication statusPublished - 2007

Fingerprint Dive into the research topics of 'Synthesis and evaluation of urea and thiourea derivatives of oxazolidinones as antibacterial agents'. Together they form a unique fingerprint.

  • Cite this