Synthesis and hypolipidemic activity of a thiazolidinone derivative

N. Jacob, G.N. Kutty

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A new molecule, incorporating a p-methoxyphenyl ring, a thiazolidin-4-one and a nicotinoyl moiety, was synthesized and evaluated for its effect on serum total cholesterol, triglyceride and transaminases in rats. The effects were compared with those of nicotinic acid, a well-known hypolipidaemic drug. The compound, 2-(4-methoxyphenyl)-3-nicotinamidothiazolidin-4-one, exhibited hypolipidaemic effect comparable with that of nicotinic acid. However, unlike nicotinic acid, it did not elevate the serum transaminase levels. The present investigation has revealed the hypolipidemic effect of the thiazolidinone derivative, which warrants a detailed study.
Original languageEnglish
Pages (from-to)76-79
Number of pages4
JournalIndian Drugs
Volume41
Issue number2
Publication statusPublished - 2004

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Niacin
Transaminases
Hypolipidemic Agents
Serum
Triglycerides
Cholesterol

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Jacob, N. ; Kutty, G.N. / Synthesis and hypolipidemic activity of a thiazolidinone derivative. In: Indian Drugs. 2004 ; Vol. 41, No. 2. pp. 76-79.
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Jacob, N & Kutty, GN 2004, 'Synthesis and hypolipidemic activity of a thiazolidinone derivative', Indian Drugs, vol. 41, no. 2, pp. 76-79.

Synthesis and hypolipidemic activity of a thiazolidinone derivative. / Jacob, N.; Kutty, G.N.

In: Indian Drugs, Vol. 41, No. 2, 2004, p. 76-79.

Research output: Contribution to journalArticle

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T1 - Synthesis and hypolipidemic activity of a thiazolidinone derivative

AU - Jacob, N.

AU - Kutty, G.N.

N1 - Cited By :18 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Kutty, G. N.; Department of Pharmacology, College of Pharmaceutical Sciences, Manipal-576119, India References: Martin-Jadraque, R., Tato, F., Mostaza, J.M., Vega, G.L., Grundy, S.M., Effectiveness of low-dose crystalline nicotinic acid in men with low high-density lipoprotein cholesterol levels (1996) Arch. Intern. Med, 156, pp. 1081-1088; Knopp, R.H., Ginsberg, J., Albers, J.J., Contrasting effects of unmodified and time-release forms of niacin on lipoproteins in hyperlipidemic subjects: Clues to mechanism of action of niacin (1985) Metabolism: Clinical and Experimental, 34 (7), pp. 642-650. , DOI 10.1016/0026-0495(85)90092-7; Carlson, L.A., Hamsten A and Asplund A: Pronounced lowering of serum levels of lipoprotein Lp (a) in hyperlipidemic subjects treated with nicotinic acid (1989) J. Intern. Med, 226, pp. 271-276; Dahlen, G.H., Lp(a) lipoprotein in cardiovascular disease (1994) Atherosclerosis, 108 (2), pp. 111-126. , DOI 10.1016/0021-9150(94)90106-6; Witztum, J.L., Current approaches to drug therapy for the hypercholesterolemic (1989) Circulation, 80 (4), pp. 1101-1113; Mahley, R.W., Bersot, T.P., Drug therapy for hypercholesterolemia and dyslipidemia (2001) Goodman and Gilman's the Pharmacological Basis of Therapeutics, pp. 971-1002. , Hardman J.G and Limbird L.C (Eds), McGraw Hill Companies Inc, 10th Ed; Kato, T., Ozaki, T., Tamura, K., Suzuki, Y., Akima, M., Ohi, N., Novel calcium antagonists with both calcium overload inhibition and antioxidant activity (1998) J. Med. Chem, 41, pp. 4309-4316; Yoshioka, T., Fujita, T., Kanai, T., Aizawa, Y., Kurumada, T., Hasegawa, K., Horikoshi, H., Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation (1989) Journal of Medicinal Chemistry, 32 (2), pp. 421-428. , DOI 10.1021/jm00122a022; Heincke, J.W., Oxidants and antioxidants in the pathogenesis of atherosclerosis (1998) Atherosclerosis, 141, pp. 1-15; Surrey, A.R., 4-Thiazolidones IV. The preparation of some substituted 3-alkylaminoalkyl-2-aryl derivatives (1949) J. Am. Chem. Soc, 71, pp. 3354-3356; Ghosh, M.N., (1984) Fundamentals of Experimental Pharmacology, pp. 154-155. , 2nd Edn, Scientific Book Agency, Calcutta; Paget, G.E., Barnes, J.M., (1964) Evaluation of Drug Activities: Pharmacometrics, 1, pp. 135-166. , (eds. Laurence, D.A and Bacharach, A.L), Academic Press, New York; Meites, S.M., Faulkner, W.R., (1962) Manual of Practical Micro and General Procedures in Clinical Chemistry, pp. 124-127. , USA; Charles C Thomas Publisher

PY - 2004

Y1 - 2004

N2 - A new molecule, incorporating a p-methoxyphenyl ring, a thiazolidin-4-one and a nicotinoyl moiety, was synthesized and evaluated for its effect on serum total cholesterol, triglyceride and transaminases in rats. The effects were compared with those of nicotinic acid, a well-known hypolipidaemic drug. The compound, 2-(4-methoxyphenyl)-3-nicotinamidothiazolidin-4-one, exhibited hypolipidaemic effect comparable with that of nicotinic acid. However, unlike nicotinic acid, it did not elevate the serum transaminase levels. The present investigation has revealed the hypolipidemic effect of the thiazolidinone derivative, which warrants a detailed study.

AB - A new molecule, incorporating a p-methoxyphenyl ring, a thiazolidin-4-one and a nicotinoyl moiety, was synthesized and evaluated for its effect on serum total cholesterol, triglyceride and transaminases in rats. The effects were compared with those of nicotinic acid, a well-known hypolipidaemic drug. The compound, 2-(4-methoxyphenyl)-3-nicotinamidothiazolidin-4-one, exhibited hypolipidaemic effect comparable with that of nicotinic acid. However, unlike nicotinic acid, it did not elevate the serum transaminase levels. The present investigation has revealed the hypolipidemic effect of the thiazolidinone derivative, which warrants a detailed study.

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JO - Indian Drugs

JF - Indian Drugs

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