Synthesis and in-vitro antimicrobial activity of 4,6 disubstituted pyrimidines

R. Bhat, G.G. Shenoy

Research output: Contribution to journalArticle

Abstract

This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.
Original languageUndefined/Unknown
Pages (from-to)553-557
Number of pages5
JournalPharmacy and Pharmacology Communications
Volume6
Issue number12
Publication statusPublished - 2000

Cite this

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abstract = "This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.",
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Synthesis and in-vitro antimicrobial activity of 4,6 disubstituted pyrimidines. / Bhat, R.; Shenoy, G.G.

In: Pharmacy and Pharmacology Communications, Vol. 6, No. 12, 2000, p. 553-557.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and in-vitro antimicrobial activity of 4,6 disubstituted pyrimidines

AU - Bhat, R.

AU - Shenoy, G.G.

N1 - cited By 0

PY - 2000

Y1 - 2000

N2 - This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.

AB - This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.

M3 - Article

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JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

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