Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro- 3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline

K.S. Girisha, B. Kalluraya, V. Narayana, Padmashree [Unknown]

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H- pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively. © 2010 Elsevier Masson SAS. All rights reserved.
Original languageEnglish
Pages (from-to)4640-4644
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number10
DOIs
Publication statusPublished - 2010

Fingerprint

hydrazine
Non-Steroidal Anti-Inflammatory Agents
Acetic Acid
Sodium
Pharmacology
Pharmaceutical Preparations
propionic acid

Cite this

@article{89ff10ec8f1d47289e4bb668d5829f4d,
title = "Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro- 3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline",
abstract = "A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H- pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively. {\circledC} 2010 Elsevier Masson SAS. All rights reserved.",
author = "K.S. Girisha and B. Kalluraya and V. Narayana and Padmashree [Unknown]",
note = "Cited By :60 Export Date: 26 November 2017 CODEN: EJMCA Correspondence Address: Kalluraya, B.; Department of Studies in Chemistry, Mangalore University, Mangalagangotri 574 199, Karnataka, India; email: bkalluraya@gmail.com Chemicals/CAS: diclofenac, 15307-79-6, 15307-86-5; hydrazine, 10217-52-4, 13775-80-9, 18500-32-8, 302-01-2, 7803-57-8; pentazocine, 359-83-1, 64024-15-3; Analgesics; Anti-Inflammatory Agents; Pyrazoles References: Patel, M.V., Bell, R., Majest, S., Henry, R., Kolasa, T., (2004) J. Org. Chem., 69, pp. 7058-7065; Damljanović, I., Vukićević, M., Radulović, N., Palić, R., Ellmerer, E., Ratković, Z., Joksović, M.D., Vukićević, R.D., (2009) Bioorg. Med. Chem. Lett., 19, pp. 1093-1096; Sharma, P.K., Kumar, S., Kumar, P., Kaushik, P., Kaushik, D., Dhingra, Y., Aneja, K.R., (2010) Eur. J. Med. Chem., 45, pp. 2650-2655; Rostom, S.A.F., Shalaby, M.A., El-Demellawy, M.A., (2003) Eur. J. Med. Chem., 38, pp. 959-974; Ghorab, M.M., Ragab, F.A., Alqasoumi, S.I., Alafeefy, A.M., Aboulmagd, S.A., (2010) Eur. J. Med. Chem., 45, pp. 171-178; Amnekar, N.D., Bhusari, K.P., (2010) Eur. J. Med. Chem., 45, pp. 149-159; Yeu, J.P., Yeh, J.T., Chen, T.Y., Uang, B.J., (2001) Synthesis, 12, p. 1775; Levai, A., (2005) Arkivok, 9, pp. 344-352; Shaharyar, M., Siddique, A.A., Ali, M.A., Sriram, D., Yogeeshwari, P., (2006) Bioorg. Med. Chem. Lett., 16, pp. 3947-3949; Rathish, I.G., Javed, K., Ahmad, S., Bano, S., Alam, M.S., Pillai, K.K., Singh, S., Bagchi, V., (2009) Bioorg. Med. Chem. Lett., 19, pp. 255-258; Bawane, B.S., Konda, S.G., Mandwad, G.G., Shaikh, B.M., (2010) Eur. J. Med. Chem., 45, pp. 171-178; Gulhan, T.H., Pierre, C., Fatma, S.K., Kevser, E., (2000) Eur. J. Med. Chem., 35 (6), pp. 635-641; Fischer, E., Knovenagel, O., (1887) Ann. Chem., 239, p. 194; Sathish Rai, N., Kalluraya, B., Lingappa, B., Shaenoy, S., Puranic, V.G., (2008) Eur. J. Med. Chem., 43, pp. 1715-1720; Kalluraya, B., Gunaga, P., Ananda, K., (1999) Indian J. Chem., 38, pp. 1295-1298; Sathish Rai, N., Kalluraya, B., (2007) Indian J. Chem., 46, pp. 375-378; Kulakarni, S.K., (1999) Hand Book of Experimental Pharmacology, , third ed. Vallabha Publications; Distasi, L.C., Costa, M., Mendacolli, S.J.L., Kirzawa, M., Games, C., Trolin, G., (1988) J. Ethnopharmacol., 24, p. 205",
year = "2010",
doi = "10.1016/j.ejmech.2010.07.032",
language = "English",
volume = "45",
pages = "4640--4644",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier Masson SAS",
number = "10",

}

Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro- 3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline. / Girisha, K.S.; Kalluraya, B.; Narayana, V.; [Unknown], Padmashree.

In: European Journal of Medicinal Chemistry, Vol. 45, No. 10, 2010, p. 4640-4644.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro- 3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline

AU - Girisha, K.S.

AU - Kalluraya, B.

AU - Narayana, V.

AU - [Unknown], Padmashree

N1 - Cited By :60 Export Date: 26 November 2017 CODEN: EJMCA Correspondence Address: Kalluraya, B.; Department of Studies in Chemistry, Mangalore University, Mangalagangotri 574 199, Karnataka, India; email: bkalluraya@gmail.com Chemicals/CAS: diclofenac, 15307-79-6, 15307-86-5; hydrazine, 10217-52-4, 13775-80-9, 18500-32-8, 302-01-2, 7803-57-8; pentazocine, 359-83-1, 64024-15-3; Analgesics; Anti-Inflammatory Agents; Pyrazoles References: Patel, M.V., Bell, R., Majest, S., Henry, R., Kolasa, T., (2004) J. Org. Chem., 69, pp. 7058-7065; Damljanović, I., Vukićević, M., Radulović, N., Palić, R., Ellmerer, E., Ratković, Z., Joksović, M.D., Vukićević, R.D., (2009) Bioorg. Med. Chem. Lett., 19, pp. 1093-1096; Sharma, P.K., Kumar, S., Kumar, P., Kaushik, P., Kaushik, D., Dhingra, Y., Aneja, K.R., (2010) Eur. J. Med. Chem., 45, pp. 2650-2655; Rostom, S.A.F., Shalaby, M.A., El-Demellawy, M.A., (2003) Eur. J. Med. Chem., 38, pp. 959-974; Ghorab, M.M., Ragab, F.A., Alqasoumi, S.I., Alafeefy, A.M., Aboulmagd, S.A., (2010) Eur. J. Med. Chem., 45, pp. 171-178; Amnekar, N.D., Bhusari, K.P., (2010) Eur. J. Med. Chem., 45, pp. 149-159; Yeu, J.P., Yeh, J.T., Chen, T.Y., Uang, B.J., (2001) Synthesis, 12, p. 1775; Levai, A., (2005) Arkivok, 9, pp. 344-352; Shaharyar, M., Siddique, A.A., Ali, M.A., Sriram, D., Yogeeshwari, P., (2006) Bioorg. Med. Chem. Lett., 16, pp. 3947-3949; Rathish, I.G., Javed, K., Ahmad, S., Bano, S., Alam, M.S., Pillai, K.K., Singh, S., Bagchi, V., (2009) Bioorg. Med. Chem. Lett., 19, pp. 255-258; Bawane, B.S., Konda, S.G., Mandwad, G.G., Shaikh, B.M., (2010) Eur. J. Med. Chem., 45, pp. 171-178; Gulhan, T.H., Pierre, C., Fatma, S.K., Kevser, E., (2000) Eur. J. Med. Chem., 35 (6), pp. 635-641; Fischer, E., Knovenagel, O., (1887) Ann. Chem., 239, p. 194; Sathish Rai, N., Kalluraya, B., Lingappa, B., Shaenoy, S., Puranic, V.G., (2008) Eur. J. Med. Chem., 43, pp. 1715-1720; Kalluraya, B., Gunaga, P., Ananda, K., (1999) Indian J. Chem., 38, pp. 1295-1298; Sathish Rai, N., Kalluraya, B., (2007) Indian J. Chem., 46, pp. 375-378; Kulakarni, S.K., (1999) Hand Book of Experimental Pharmacology, , third ed. Vallabha Publications; Distasi, L.C., Costa, M., Mendacolli, S.J.L., Kirzawa, M., Games, C., Trolin, G., (1988) J. Ethnopharmacol., 24, p. 205

PY - 2010

Y1 - 2010

N2 - A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H- pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively. © 2010 Elsevier Masson SAS. All rights reserved.

AB - A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H- pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively. © 2010 Elsevier Masson SAS. All rights reserved.

U2 - 10.1016/j.ejmech.2010.07.032

DO - 10.1016/j.ejmech.2010.07.032

M3 - Article

VL - 45

SP - 4640

EP - 4644

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

IS - 10

ER -