Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro- 3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline

K.S. Girisha, B. Kalluraya, V. Narayana, Padmashree [Unknown]

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H- pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively. © 2010 Elsevier Masson SAS. All rights reserved.
Original languageEnglish
Pages (from-to)4640-4644
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number10
DOIs
Publication statusPublished - 2010

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