Synthesis, anti-proliferative and genotoxicity studies of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2 H-indol-2-ones and 6-chloro-5-(2-chloroethyl)-3-(alkyl/ary-2-ylidene)indolin-2-ones

Gangadhar Y. Meti, Atulkumar A. Kamble, Ravindra R. Kamble, Shilpa M. Somagond, H. C. Devarajegowda, Sandhya Kumari, Guruprasad Kalthur, Satish K. Adiga

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A series of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones (3a-h) and 6-chloro-5-(2-chloroethyl)-3-(alkyl/aryl-2-ylidene)indolin-2-ones (5i-x) were synthesized. Compounds 3a-e, 5i-l and 5q-r were selected by NIH, USA for in vitro anti-proliferative screening. Based on the impressive growth inhibitory (GI %) effect by the compounds 3a-b and 3e which showed growth inhibition in the range 1.22-76.30%, 2.85-76.03% and 10.98-82.05% respectively at 10ĝ'5 concentration, these compounds were further analyzed for anti-proliferative activity at 5 dose concentration and genotoxicity.

Original languageEnglish
Pages (from-to)221-231
Number of pages11
JournalEuropean Journal of Medicinal Chemistry
Volume121
DOIs
Publication statusPublished - 04-10-2016

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Growth
Screening
indolin-2-one
In Vitro Techniques
2-oxindole

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

@article{1cb9ee443c984ca39563db0994bdcd63,
title = "Synthesis, anti-proliferative and genotoxicity studies of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2 H-indol-2-ones and 6-chloro-5-(2-chloroethyl)-3-(alkyl/ary-2-ylidene)indolin-2-ones",
abstract = "A series of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones (3a-h) and 6-chloro-5-(2-chloroethyl)-3-(alkyl/aryl-2-ylidene)indolin-2-ones (5i-x) were synthesized. Compounds 3a-e, 5i-l and 5q-r were selected by NIH, USA for in vitro anti-proliferative screening. Based on the impressive growth inhibitory (GI {\%}) effect by the compounds 3a-b and 3e which showed growth inhibition in the range 1.22-76.30{\%}, 2.85-76.03{\%} and 10.98-82.05{\%} respectively at 10ĝ'5 concentration, these compounds were further analyzed for anti-proliferative activity at 5 dose concentration and genotoxicity.",
author = "Meti, {Gangadhar Y.} and Kamble, {Atulkumar A.} and Kamble, {Ravindra R.} and Somagond, {Shilpa M.} and Devarajegowda, {H. C.} and Sandhya Kumari and Guruprasad Kalthur and Adiga, {Satish K.}",
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publisher = "Elsevier Masson SAS",

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Synthesis, anti-proliferative and genotoxicity studies of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2 H-indol-2-ones and 6-chloro-5-(2-chloroethyl)-3-(alkyl/ary-2-ylidene)indolin-2-ones. / Meti, Gangadhar Y.; Kamble, Atulkumar A.; Kamble, Ravindra R.; Somagond, Shilpa M.; Devarajegowda, H. C.; Kumari, Sandhya; Kalthur, Guruprasad; Adiga, Satish K.

In: European Journal of Medicinal Chemistry, Vol. 121, 04.10.2016, p. 221-231.

Research output: Contribution to journalArticle

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AU - Meti, Gangadhar Y.

AU - Kamble, Atulkumar A.

AU - Kamble, Ravindra R.

AU - Somagond, Shilpa M.

AU - Devarajegowda, H. C.

AU - Kumari, Sandhya

AU - Kalthur, Guruprasad

AU - Adiga, Satish K.

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