Synthesis, anti-proliferative and genotoxicity studies of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2 H-indol-2-ones and 6-chloro-5-(2-chloroethyl)-3-(alkyl/ary-2-ylidene)indolin-2-ones

Gangadhar Y. Meti, Atulkumar A. Kamble, Ravindra R. Kamble, Shilpa M. Somagond, H. C. Devarajegowda, Sandhya Kumari, Guruprasad Kalthur, Satish K. Adiga

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Abstract

A series of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones (3a-h) and 6-chloro-5-(2-chloroethyl)-3-(alkyl/aryl-2-ylidene)indolin-2-ones (5i-x) were synthesized. Compounds 3a-e, 5i-l and 5q-r were selected by NIH, USA for in vitro anti-proliferative screening. Based on the impressive growth inhibitory (GI %) effect by the compounds 3a-b and 3e which showed growth inhibition in the range 1.22-76.30%, 2.85-76.03% and 10.98-82.05% respectively at 10ĝ'5 concentration, these compounds were further analyzed for anti-proliferative activity at 5 dose concentration and genotoxicity.

Original languageEnglish
Pages (from-to)221-231
Number of pages11
JournalEuropean Journal of Medicinal Chemistry
Volume121
DOIs
Publication statusPublished - 04-10-2016

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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