Synthesis, antimicrobial evaluation and docking studies of novel quinoline carboxamide analogs

Gaikwad Kiran Narayan, Kini Suvarna Ganesh, Saxena Akashdeen, Martina Suganthi, Ballal Mamatha, Muhammad Mubeen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A series of twenty novel quinoline carboxamide analogues have been synthesized. Treatment of different anilines with quinoline carboxylic acid derivative was carried out to yield the desired product. A series of compounds from 1a-1t were synthesized, characterized by physical and spectral data and evaluated for their antimicrobial activity using disc plate method at 200ug/ml concentration using ciprofloxacin as standard which had initial zone of inhibition of 23mm. Compounds 1a, 1b, 1k to 1o gave promising activity against Aeromonas and compounds 1f to1q and 1s and 1t were active against Enterococcus species. Docking studies were carried out to study the interaction of these analogues with the target Aeromonas hydrophila.

Original languageEnglish
Article number63
Pages (from-to)344-348
Number of pages5
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume41
Issue number2
Publication statusPublished - 01-11-2016

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Aniline Compounds
Aeromonas hydrophila
Aeromonas
Enterococcus
Ciprofloxacin
Carboxylic Acids
quinoline

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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Synthesis, antimicrobial evaluation and docking studies of novel quinoline carboxamide analogs. / Narayan, Gaikwad Kiran; Ganesh, Kini Suvarna; Akashdeen, Saxena; Suganthi, Martina; Mamatha, Ballal; Mubeen, Muhammad.

In: International Journal of Pharmaceutical Sciences Review and Research, Vol. 41, No. 2, 63, 01.11.2016, p. 344-348.

Research output: Contribution to journalArticle

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