Synthesis, characterization and antibacterial activity studies on some fluorine containing quinoline-4-carboxylic acids and their derivatives

B. Shivarama Holla, K. Narayana Poojary, Boja Poojary, K. Subrahmanya Bhat, N. Suchetha Kumari

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A series of 3-substituted-1,2,4-triazolo[3,4-6]-1,3,4-thiadiazol-6-yl-2-(2, 4-dichloro-5-fluorophenyl)quinolines 5 have been synthesized by the condensation of hitherto unreported quinoline-4-carboxylic acids 3 with various 3-substituted-4-amino-5-mercapto-1,2,4-triazoles 4. The structures of newly synthesized compounds have been confirmed on the basis of elemental analysis, IR, 1H NMR and mass spectral data. The newly synthesized compounds are evaluated for their antibacterial activities.

Original languageEnglish
Pages (from-to)2114-2119
Number of pages6
JournalIndian Journal of Chemistry - Section B Organic and Medicinal Chemistry
Volume44
Issue number10
Publication statusPublished - 10-2005

Fingerprint

Quinolines
Fluorine
Condensation
Nuclear magnetic resonance
Derivatives
Chemical analysis
1,2,4-triazole
quinoline-4-carboxylic acid
Proton Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

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abstract = "A series of 3-substituted-1,2,4-triazolo[3,4-6]-1,3,4-thiadiazol-6-yl-2-(2, 4-dichloro-5-fluorophenyl)quinolines 5 have been synthesized by the condensation of hitherto unreported quinoline-4-carboxylic acids 3 with various 3-substituted-4-amino-5-mercapto-1,2,4-triazoles 4. The structures of newly synthesized compounds have been confirmed on the basis of elemental analysis, IR, 1H NMR and mass spectral data. The newly synthesized compounds are evaluated for their antibacterial activities.",
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Synthesis, characterization and antibacterial activity studies on some fluorine containing quinoline-4-carboxylic acids and their derivatives. / Holla, B. Shivarama; Poojary, K. Narayana; Poojary, Boja; Bhat, K. Subrahmanya; Kumari, N. Suchetha.

In: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, Vol. 44, No. 10, 10.2005, p. 2114-2119.

Research output: Contribution to journalArticle

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AU - Holla, B. Shivarama

AU - Poojary, K. Narayana

AU - Poojary, Boja

AU - Bhat, K. Subrahmanya

AU - Kumari, N. Suchetha

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