TY - JOUR
T1 - Synthesis, characterization and anticancer evaluation of novel analogues of pyrazoles
AU - Khatun, Babli
AU - Kamath, Venkatesh
AU - Muddukrishna, B. S.
AU - Pai, Aravinda
N1 - Funding Information:
Authors acknowledge Manipal Academy of Higher Education for the support provided to carry out the present research.
Publisher Copyright:
© RJPT All right reserved.
PY - 2021/4
Y1 - 2021/4
N2 - In the present study, a series of novel substituted pyrazole chalcones and pyrazole oximes (CF 1-15) were synthesized and characterized. Logp values were determined to assess their hydrophobicity. MTT (methyl tetrazolium) assay was performed on A-549 (lung cancer) cell lines. The MTT assay results showed the effect of various substituents on the pyrazole template that could influence their cytotoxic effect. Out of the 15 compounds screened against A-549 cell lines, the compound CF-6 showed appreciable cytotoxicity against the standard doxorubicin.
AB - In the present study, a series of novel substituted pyrazole chalcones and pyrazole oximes (CF 1-15) were synthesized and characterized. Logp values were determined to assess their hydrophobicity. MTT (methyl tetrazolium) assay was performed on A-549 (lung cancer) cell lines. The MTT assay results showed the effect of various substituents on the pyrazole template that could influence their cytotoxic effect. Out of the 15 compounds screened against A-549 cell lines, the compound CF-6 showed appreciable cytotoxicity against the standard doxorubicin.
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U2 - 10.52711/0974-360X.2021.00382
DO - 10.52711/0974-360X.2021.00382
M3 - Article
AN - SCOPUS:85108276161
SN - 0974-3618
VL - 14
SP - 2162
EP - 2166
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 4
ER -
