Synthesis, characterization and antimicrobial activity of 7-Amino-2-Styrylchromones

Amita S. Rao, Lalitha Simon, K. K. Srinivasan, K. L. Shobha, B. C. Ganesh Maiya

Research output: Contribution to journalArticle

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Abstract

Nine derivatives of 7-Amino-2-Styrylchromones (3a-i) were synthesized and characterized. These compounds were examined for their antibacterial activity against the bacterial strains Klebsiella pneumonia, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and antifungal activity against Candida albicans. Klebsiella pneumoniae was found to be resistant to multiple antibiotics such as ampicillin, amoxicillin/ clavulanic acid, gentamycin, amikacin, levofloxacin, imipenem, cefazolin and cefepime. However all the test compounds(3a-i) showed good activity against Klebsiella pneumoniae at 12.5μg /mL concentration. Compound 3dat12.5μg /mL concentration displayed a zone of inhibition of 25mm against Staphylococcus aureus.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalDer Pharma Chemica
Volume8
Issue number7
Publication statusPublished - 2016

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Amoxicillin-Potassium Clavulanate Combination
Cefazolin
Levofloxacin
Amikacin
Imipenem
Candida
Ampicillin
Gentamicins
Escherichia coli
Anti-Bacterial Agents
Derivatives
cefepime

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Rao, Amita S. ; Simon, Lalitha ; Srinivasan, K. K. ; Shobha, K. L. ; Ganesh Maiya, B. C. / Synthesis, characterization and antimicrobial activity of 7-Amino-2-Styrylchromones. In: Der Pharma Chemica. 2016 ; Vol. 8, No. 7. pp. 157-160.
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Rao, AS, Simon, L, Srinivasan, KK, Shobha, KL & Ganesh Maiya, BC 2016, 'Synthesis, characterization and antimicrobial activity of 7-Amino-2-Styrylchromones', Der Pharma Chemica, vol. 8, no. 7, pp. 157-160.

Synthesis, characterization and antimicrobial activity of 7-Amino-2-Styrylchromones. / Rao, Amita S.; Simon, Lalitha; Srinivasan, K. K.; Shobha, K. L.; Ganesh Maiya, B. C.

In: Der Pharma Chemica, Vol. 8, No. 7, 2016, p. 157-160.

Research output: Contribution to journalArticle

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T1 - Synthesis, characterization and antimicrobial activity of 7-Amino-2-Styrylchromones

AU - Rao, Amita S.

AU - Simon, Lalitha

AU - Srinivasan, K. K.

AU - Shobha, K. L.

AU - Ganesh Maiya, B. C.

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AB - Nine derivatives of 7-Amino-2-Styrylchromones (3a-i) were synthesized and characterized. These compounds were examined for their antibacterial activity against the bacterial strains Klebsiella pneumonia, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and antifungal activity against Candida albicans. Klebsiella pneumoniae was found to be resistant to multiple antibiotics such as ampicillin, amoxicillin/ clavulanic acid, gentamycin, amikacin, levofloxacin, imipenem, cefazolin and cefepime. However all the test compounds(3a-i) showed good activity against Klebsiella pneumoniae at 12.5μg /mL concentration. Compound 3dat12.5μg /mL concentration displayed a zone of inhibition of 25mm against Staphylococcus aureus.

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