Synthesis, characterization and antimicrobial activity of novel ethyl 1-(N-substituted)-5-phenyl-1H-pyrazole-4-carboxylate derivatives

B. Chandrakantha, Arun M. Isloor, Prakash Shetty, Shrikrishna Isloor, Shridhar Malladi, Hoong Kun Fun

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In the present study, a novel series of Pyrazole derivatives (3a-m) were synthesized by condensing ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2- enoate with different aromatic and aliphatic hydrazines. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral studies as well as by C, H, and N analyses. All the newly synthesized compounds were screened for their antibacterial properties against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. Among the screened samples, 3c, 3f, 3k, and 3l have showed excellent antibacterial activity against all the tested bacterial strains as compared to the standard drug Ceftriaxone. Few of the compounds were found to be biologically potent. Molecular structure of compound 3i was confirmed by single crystal X-ray analysis.

Original languageEnglish
Pages (from-to)2702-2708
Number of pages7
JournalMedicinal Chemistry Research
Volume21
Issue number9
DOIs
Publication statusPublished - 01-09-2012

Fingerprint

Hydrazines
Ceftriaxone
X ray analysis
Bacilli
Bacillus subtilis
Molecular Structure
Pseudomonas aeruginosa
Escherichia coli
Molecular structure
Staphylococcus aureus
Nuclear magnetic resonance
X-Rays
Single crystals
Derivatives
Pharmaceutical Preparations
pyrazole

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Chandrakantha, B. ; Isloor, Arun M. ; Shetty, Prakash ; Isloor, Shrikrishna ; Malladi, Shridhar ; Fun, Hoong Kun. / Synthesis, characterization and antimicrobial activity of novel ethyl 1-(N-substituted)-5-phenyl-1H-pyrazole-4-carboxylate derivatives. In: Medicinal Chemistry Research. 2012 ; Vol. 21, No. 9. pp. 2702-2708.
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Synthesis, characterization and antimicrobial activity of novel ethyl 1-(N-substituted)-5-phenyl-1H-pyrazole-4-carboxylate derivatives. / Chandrakantha, B.; Isloor, Arun M.; Shetty, Prakash; Isloor, Shrikrishna; Malladi, Shridhar; Fun, Hoong Kun.

In: Medicinal Chemistry Research, Vol. 21, No. 9, 01.09.2012, p. 2702-2708.

Research output: Contribution to journalArticle

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