Synthesis, characterization and antimicrobial activity of some 2,5-disubstituted-3-acetyl-[1,3,4]-oxadiazoles carrying 2-(aryloxymethyl) phenyl moiety

C. S. Naveena, Boja Poojary, Manjunath Kumsi, Arulmoli Thangavel, Shalini Shenoy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A series of 3-acetyl-2-aryl-5-[2-(aryloxymethyl)phenyl]-2,3-dihydro-[1,3,4]-oxadiazoles (4a-p) have been synthesized and evaluated for their antimicrobial activity. Initially, the acid hydrazides (2a-d) derived from 2-(aryloxymethyl) benzoic acids (1a-d) were reacted with various aromatic aldehydes to yield hydrazones (3a-p). Further reaction of these hydrazones with acetic anhydride afforded the title compounds. All structures of the new compounds were established on the basis of their elemental analyses, IR, 1H NMR, 13C NMR and mass spectral data. The newly synthesized compounds were evaluated for their antimicrobial activities. Preliminary results indicated that some of them exhibit promising activities and they deserve more consideration as potential antimicrobial agents.

Original languageEnglish
Pages (from-to)247-257
Number of pages11
JournalDer Pharma Chemica
Volume3
Issue number6
Publication statusPublished - 01-12-2011

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Hydrazones
Nuclear magnetic resonance
Benzoates
Anti-Infective Agents
Aldehydes
Acids
1,3,4-oxadiazole
acetic anhydride

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

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abstract = "A series of 3-acetyl-2-aryl-5-[2-(aryloxymethyl)phenyl]-2,3-dihydro-[1,3,4]-oxadiazoles (4a-p) have been synthesized and evaluated for their antimicrobial activity. Initially, the acid hydrazides (2a-d) derived from 2-(aryloxymethyl) benzoic acids (1a-d) were reacted with various aromatic aldehydes to yield hydrazones (3a-p). Further reaction of these hydrazones with acetic anhydride afforded the title compounds. All structures of the new compounds were established on the basis of their elemental analyses, IR, 1H NMR, 13C NMR and mass spectral data. The newly synthesized compounds were evaluated for their antimicrobial activities. Preliminary results indicated that some of them exhibit promising activities and they deserve more consideration as potential antimicrobial agents.",
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Synthesis, characterization and antimicrobial activity of some 2,5-disubstituted-3-acetyl-[1,3,4]-oxadiazoles carrying 2-(aryloxymethyl) phenyl moiety. / Naveena, C. S.; Poojary, Boja; Kumsi, Manjunath; Thangavel, Arulmoli; Shenoy, Shalini.

In: Der Pharma Chemica, Vol. 3, No. 6, 01.12.2011, p. 247-257.

Research output: Contribution to journalArticle

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AU - Shenoy, Shalini

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