Synthesis, characterization and antimicrobial activity of some new 1,3,4-oxadiazoles and schiff bases bearing 5-chloroquinolin-8-ol moiety

B. Chandrashekhar Kumar, K. R. Venugopala Reddy, Fasiulla

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A new series of 2-(substituted phenyl)-5-(5-chloro quinolin-8-yloxy) methyl-1,3,4-oxadiazole (3a-j) were synthesised after refluxing 2-[(5-chloro quinolin-8-yl) oxy] acetohydrazide (2) with different aromatic acids in presence of POCl3. A new series of N'-(substituted benzylidene)-2-(5-chloro-8-yloxy) acetohydrazide (schiff' bases) (4a-j)were also synthesized from a mixture of2-[(5-chloro quinolin-8-yl) oxy] acetohydrazide (2)and different aromatic aldehydes in presence of glacial acetic acid. The chemical structures of these compounds were confirmed by various physic-chemical methods viz, IR, 1HNMR, mass spectral data and elemental analysis. Newly synthesized compounds were screened in vitro for their antimicrobial activity against varieties of gram +ve and gramve bacterial strains such as Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and fungi strains Candida albicans & Aspergillus nigar with MIC at 40 μg/mL. The newly synthesized Schiff bases and 1,3,4-Oxadiazole derivatives bearing 5-chloroquinolin-8-ol are showing moderate to highly significant antimicrobial activity. The Schiff base (4i) shows highly significant antimicrobial activity as compare to other synthesized Schiff bases.

Original languageEnglish
Pages (from-to)154-161
Number of pages8
JournalJournal of Chemical and Pharmaceutical Research
Volume5
Issue number8
Publication statusPublished - 25-09-2013
Externally publishedYes

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Schiff Bases
Physics
Aspergillus
Bacillus subtilis
Candida albicans
Aldehydes
Acetic Acid
Pseudomonas aeruginosa
Staphylococcus aureus
Fungi
Escherichia coli
Acids
1,3,4-oxadiazole
cloxyquin

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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title = "Synthesis, characterization and antimicrobial activity of some new 1,3,4-oxadiazoles and schiff bases bearing 5-chloroquinolin-8-ol moiety",
abstract = "A new series of 2-(substituted phenyl)-5-(5-chloro quinolin-8-yloxy) methyl-1,3,4-oxadiazole (3a-j) were synthesised after refluxing 2-[(5-chloro quinolin-8-yl) oxy] acetohydrazide (2) with different aromatic acids in presence of POCl3. A new series of N'-(substituted benzylidene)-2-(5-chloro-8-yloxy) acetohydrazide (schiff' bases) (4a-j)were also synthesized from a mixture of2-[(5-chloro quinolin-8-yl) oxy] acetohydrazide (2)and different aromatic aldehydes in presence of glacial acetic acid. The chemical structures of these compounds were confirmed by various physic-chemical methods viz, IR, 1HNMR, mass spectral data and elemental analysis. Newly synthesized compounds were screened in vitro for their antimicrobial activity against varieties of gram +ve and gramve bacterial strains such as Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and fungi strains Candida albicans & Aspergillus nigar with MIC at 40 μg/mL. The newly synthesized Schiff bases and 1,3,4-Oxadiazole derivatives bearing 5-chloroquinolin-8-ol are showing moderate to highly significant antimicrobial activity. The Schiff base (4i) shows highly significant antimicrobial activity as compare to other synthesized Schiff bases.",
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Synthesis, characterization and antimicrobial activity of some new 1,3,4-oxadiazoles and schiff bases bearing 5-chloroquinolin-8-ol moiety. / Kumar, B. Chandrashekhar; Venugopala Reddy, K. R.; Fasiulla.

In: Journal of Chemical and Pharmaceutical Research, Vol. 5, No. 8, 25.09.2013, p. 154-161.

Research output: Contribution to journalArticle

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T1 - Synthesis, characterization and antimicrobial activity of some new 1,3,4-oxadiazoles and schiff bases bearing 5-chloroquinolin-8-ol moiety

AU - Kumar, B. Chandrashekhar

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AU - Fasiulla,

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AB - A new series of 2-(substituted phenyl)-5-(5-chloro quinolin-8-yloxy) methyl-1,3,4-oxadiazole (3a-j) were synthesised after refluxing 2-[(5-chloro quinolin-8-yl) oxy] acetohydrazide (2) with different aromatic acids in presence of POCl3. A new series of N'-(substituted benzylidene)-2-(5-chloro-8-yloxy) acetohydrazide (schiff' bases) (4a-j)were also synthesized from a mixture of2-[(5-chloro quinolin-8-yl) oxy] acetohydrazide (2)and different aromatic aldehydes in presence of glacial acetic acid. The chemical structures of these compounds were confirmed by various physic-chemical methods viz, IR, 1HNMR, mass spectral data and elemental analysis. Newly synthesized compounds were screened in vitro for their antimicrobial activity against varieties of gram +ve and gramve bacterial strains such as Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and fungi strains Candida albicans & Aspergillus nigar with MIC at 40 μg/mL. The newly synthesized Schiff bases and 1,3,4-Oxadiazole derivatives bearing 5-chloroquinolin-8-ol are showing moderate to highly significant antimicrobial activity. The Schiff base (4i) shows highly significant antimicrobial activity as compare to other synthesized Schiff bases.

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