Synthesis, characterization and antimicrobial activity of some novel 2,3-disubstituted thiazolidin-4-one derivatives

B. Chandrashekhar Kumar, K. R. Venugopala Reddy, Fasiulla, A. M. Shridhara

Research output: Contribution to journalArticle

Abstract

A series of new 3-(4-(p-toluidino)thiazol-2-yl)-2-phenylthiazolidin-4-one derivatives (5a-g) were synthesized from novel schiff base of 2-((4-(p-toluidino)thiazol-2-ylimino)methyl)phenol (4a-g) with thioglycolic acid in presence of anhydrous zinc chloride. The chemical structures of these compounds were confirmed by various physic-chemical methods viz, IR, 1H NMR, mass spectral data and elemental analysis. Newly synthesized compounds were screened in vitro for their antimicrobial activity against varieties of gram +ve and gram -ve bacterial strains such as Bacillus subtilis, Pseudomonas aeruginosa and fungi strain Candida albicans & Aspergillus nigar at 40 μg/mL. The chloro and bromo substituted 2,3-substituted thiazolidin-4-one derivatives are showing activity as compare to the other functional groups.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Chemical and Pharmaceutical Research
Volume5
Issue number6
Publication statusPublished - 01-08-2013
Externally publishedYes

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Schiff Bases
Physics
Aspergillus
Phenol
Bacillus subtilis
Candida albicans
Pseudomonas aeruginosa
Fungi
zinc chloride
2-mercaptoacetate
In Vitro Techniques
Proton Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Chandrashekhar Kumar, B. ; Venugopala Reddy, K. R. ; Fasiulla ; Shridhara, A. M. / Synthesis, characterization and antimicrobial activity of some novel 2,3-disubstituted thiazolidin-4-one derivatives. In: Journal of Chemical and Pharmaceutical Research. 2013 ; Vol. 5, No. 6. pp. 1-6.
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abstract = "A series of new 3-(4-(p-toluidino)thiazol-2-yl)-2-phenylthiazolidin-4-one derivatives (5a-g) were synthesized from novel schiff base of 2-((4-(p-toluidino)thiazol-2-ylimino)methyl)phenol (4a-g) with thioglycolic acid in presence of anhydrous zinc chloride. The chemical structures of these compounds were confirmed by various physic-chemical methods viz, IR, 1H NMR, mass spectral data and elemental analysis. Newly synthesized compounds were screened in vitro for their antimicrobial activity against varieties of gram +ve and gram -ve bacterial strains such as Bacillus subtilis, Pseudomonas aeruginosa and fungi strain Candida albicans & Aspergillus nigar at 40 μg/mL. The chloro and bromo substituted 2,3-substituted thiazolidin-4-one derivatives are showing activity as compare to the other functional groups.",
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Synthesis, characterization and antimicrobial activity of some novel 2,3-disubstituted thiazolidin-4-one derivatives. / Chandrashekhar Kumar, B.; Venugopala Reddy, K. R.; Fasiulla; Shridhara, A. M.

In: Journal of Chemical and Pharmaceutical Research, Vol. 5, No. 6, 01.08.2013, p. 1-6.

Research output: Contribution to journalArticle

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