Synthesis, characterization and antimicrobial, antioxidant properties of some benzopyrone derivatives

B.S. Jayashree, B.K. Kuppast, K.N. Venugopala

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The purpose of present study is to develop potential antimicrobial and antioxidant agents. In this attempt three series of the substituted flavones such as 3-hydroxy flavones (4a-j), 3-methoxy flavones (5a-e) and 3-acetyloxy flavones (6a-g) were synthesized and characterized by IR, 1H NMR and mass spectral analysis. Test compounds were subjected for the determination of lipophillic parameter and pharmacological activities such as quantitative antibacterial activity and antioxidant activity by MIC (ELISA) and DPPH* method, respectively.
Original languageEnglish
Pages (from-to)1415-1422
Number of pages8
JournalAsian Journal of Chemistry
Volume19
Issue number2
Publication statusPublished - 2007

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Flavones
Antioxidants
Derivatives
Spectrum analysis
Nuclear magnetic resonance

Cite this

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abstract = "The purpose of present study is to develop potential antimicrobial and antioxidant agents. In this attempt three series of the substituted flavones such as 3-hydroxy flavones (4a-j), 3-methoxy flavones (5a-e) and 3-acetyloxy flavones (6a-g) were synthesized and characterized by IR, 1H NMR and mass spectral analysis. Test compounds were subjected for the determination of lipophillic parameter and pharmacological activities such as quantitative antibacterial activity and antioxidant activity by MIC (ELISA) and DPPH* method, respectively.",
author = "B.S. Jayashree and B.K. Kuppast and K.N. Venugopala",
note = "Cited By :4 Export Date: 10 November 2017 CODEN: AJCHE Correspondence Address: Jayashree, B.S.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal-576104, India; email: alameenpc@hotmail.com References: Karale, B.K., Hangargo, R.V., Mane, A.S., Gill, C.H., Shingare, M.S., (2001) Indian J. Heterocycl. Chem, 11, p. 81; Emim, J.A.D.S., Oliveira, A.B., Lapa, A.J., (1992) J. Pharm. Pharmacol, 46, p. 118; Malterud, K.E., Diep, O.H., Sund, R.B., (1996) Pharmacol. Toxic, 78, p. 111; Nakane, H., Ono, K., (1990) Biochemistry, 29, p. 2841; Cassady, J.M., (1990) J. Nat. Prod, 35, p. 23; Imai, K., Nakachi, K., (1995) British Med. J, 310, p. 693; Fritz, B., Tobias, S., Albrecht, K., Charlotte, B., Kent, C., Anni, A., Franz, J., Joseph, K., (1996) Am. Soc. Biochem. Mol. Bio, 271, p. 2262; I. L. Finar, Organic Chemistry, Pearson Education, (Singapore) Pvt. Ltd., edn. 6, 1, p. 704 (2003); Lynda, L.S., Jerome, K.W., Sang, K., Lee, C.G., Daiel, L., Richard, C.M., Robert, M.M., John, M.P., (1991) Cancer Res, 59, p. 578; Garg, C.P., Sharma, V.P., Kapoor, R.P., (1985) Indian J. Chem, 24 B, p. 1197; http://www.niaid.nih.gov; Vani, T., Rajani, M., Sarkar, S., Shishhoo, C.J., (1997) Int. J. Pharmacog, 35, p. 313; Kavanagh, F., (1963) Analytical Microbiology, p. 125. , Academic Press, New York, p; Lowdi, E., Odenholt, I., Bengtsson, S., Cars, O., (1993) Antimicrob. Agents Chemother, 37, p. 2200",
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Synthesis, characterization and antimicrobial, antioxidant properties of some benzopyrone derivatives. / Jayashree, B.S.; Kuppast, B.K.; Venugopala, K.N.

In: Asian Journal of Chemistry, Vol. 19, No. 2, 2007, p. 1415-1422.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis, characterization and antimicrobial, antioxidant properties of some benzopyrone derivatives

AU - Jayashree, B.S.

AU - Kuppast, B.K.

AU - Venugopala, K.N.

N1 - Cited By :4 Export Date: 10 November 2017 CODEN: AJCHE Correspondence Address: Jayashree, B.S.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal-576104, India; email: alameenpc@hotmail.com References: Karale, B.K., Hangargo, R.V., Mane, A.S., Gill, C.H., Shingare, M.S., (2001) Indian J. Heterocycl. Chem, 11, p. 81; Emim, J.A.D.S., Oliveira, A.B., Lapa, A.J., (1992) J. Pharm. Pharmacol, 46, p. 118; Malterud, K.E., Diep, O.H., Sund, R.B., (1996) Pharmacol. Toxic, 78, p. 111; Nakane, H., Ono, K., (1990) Biochemistry, 29, p. 2841; Cassady, J.M., (1990) J. Nat. Prod, 35, p. 23; Imai, K., Nakachi, K., (1995) British Med. J, 310, p. 693; Fritz, B., Tobias, S., Albrecht, K., Charlotte, B., Kent, C., Anni, A., Franz, J., Joseph, K., (1996) Am. Soc. Biochem. Mol. Bio, 271, p. 2262; I. L. Finar, Organic Chemistry, Pearson Education, (Singapore) Pvt. Ltd., edn. 6, 1, p. 704 (2003); Lynda, L.S., Jerome, K.W., Sang, K., Lee, C.G., Daiel, L., Richard, C.M., Robert, M.M., John, M.P., (1991) Cancer Res, 59, p. 578; Garg, C.P., Sharma, V.P., Kapoor, R.P., (1985) Indian J. Chem, 24 B, p. 1197; http://www.niaid.nih.gov; Vani, T., Rajani, M., Sarkar, S., Shishhoo, C.J., (1997) Int. J. Pharmacog, 35, p. 313; Kavanagh, F., (1963) Analytical Microbiology, p. 125. , Academic Press, New York, p; Lowdi, E., Odenholt, I., Bengtsson, S., Cars, O., (1993) Antimicrob. Agents Chemother, 37, p. 2200

PY - 2007

Y1 - 2007

N2 - The purpose of present study is to develop potential antimicrobial and antioxidant agents. In this attempt three series of the substituted flavones such as 3-hydroxy flavones (4a-j), 3-methoxy flavones (5a-e) and 3-acetyloxy flavones (6a-g) were synthesized and characterized by IR, 1H NMR and mass spectral analysis. Test compounds were subjected for the determination of lipophillic parameter and pharmacological activities such as quantitative antibacterial activity and antioxidant activity by MIC (ELISA) and DPPH* method, respectively.

AB - The purpose of present study is to develop potential antimicrobial and antioxidant agents. In this attempt three series of the substituted flavones such as 3-hydroxy flavones (4a-j), 3-methoxy flavones (5a-e) and 3-acetyloxy flavones (6a-g) were synthesized and characterized by IR, 1H NMR and mass spectral analysis. Test compounds were subjected for the determination of lipophillic parameter and pharmacological activities such as quantitative antibacterial activity and antioxidant activity by MIC (ELISA) and DPPH* method, respectively.

M3 - Article

VL - 19

SP - 1415

EP - 1422

JO - Asian Journal of Chemistry

JF - Asian Journal of Chemistry

SN - 0970-7077

IS - 2

ER -