Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives

A. M. Vijesh, Arun M. Isloor, Sandeep Telkar, S. K. Peethambar, Sankappa Rai, Nishitha Isloor

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In the present study two series of novel imidazole derivatives containing substituted pyrazole moiety (3a-d and 5a-j) were synthesized. The first series were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazones (2a-d) with DMAD and the second series by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes (1a-e) with 1,2-diketones (4a,b) in the presence of ammonium acetate. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for antifungal and antibacterial activities. Among the synthesized compounds, compound 3c was found to be potent antimicrobial agent. The acute oral toxicity study for the compound 3c was carried out and the experimental studies revealed that compound 3c is safe up to 3000 mg/kg and no death of animals were recorded.

Original languageEnglish
Pages (from-to)3531-3536
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Issue number8
Publication statusPublished - 01-08-2011
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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