Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives

A. M. Vijesh, Arun M. Isloor, Sandeep Telkar, S. K. Peethambar, Sankappa Rai, Nishitha Isloor

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

In the present study two series of novel imidazole derivatives containing substituted pyrazole moiety (3a-d and 5a-j) were synthesized. The first series were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazones (2a-d) with DMAD and the second series by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes (1a-e) with 1,2-diketones (4a,b) in the presence of ammonium acetate. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for antifungal and antibacterial activities. Among the synthesized compounds, compound 3c was found to be potent antimicrobial agent. The acute oral toxicity study for the compound 3c was carried out and the experimental studies revealed that compound 3c is safe up to 3000 mg/kg and no death of animals were recorded.

Original languageEnglish
Pages (from-to)3531-3536
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Volume46
Issue number8
DOIs
Publication statusPublished - 01-08-2011
Externally publishedYes

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Derivatives
Thiosemicarbazones
Anti-Infective Agents
Toxicity
Animals
imidazole
pyrazole
ammonium acetate

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Vijesh, A. M. ; Isloor, Arun M. ; Telkar, Sandeep ; Peethambar, S. K. ; Rai, Sankappa ; Isloor, Nishitha. / Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. In: European Journal of Medicinal Chemistry. 2011 ; Vol. 46, No. 8. pp. 3531-3536.
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Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. / Vijesh, A. M.; Isloor, Arun M.; Telkar, Sandeep; Peethambar, S. K.; Rai, Sankappa; Isloor, Nishitha.

In: European Journal of Medicinal Chemistry, Vol. 46, No. 8, 01.08.2011, p. 3531-3536.

Research output: Contribution to journalArticle

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