Abstract
In the present study two series of novel imidazole derivatives containing substituted pyrazole moiety (3a-d and 5a-j) were synthesized. The first series were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazones (2a-d) with DMAD and the second series by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes (1a-e) with 1,2-diketones (4a,b) in the presence of ammonium acetate. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for antifungal and antibacterial activities. Among the synthesized compounds, compound 3c was found to be potent antimicrobial agent. The acute oral toxicity study for the compound 3c was carried out and the experimental studies revealed that compound 3c is safe up to 3000 mg/kg and no death of animals were recorded.
| Original language | English |
|---|---|
| Pages (from-to) | 3531-3536 |
| Number of pages | 6 |
| Journal | European Journal of Medicinal Chemistry |
| Volume | 46 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 01-08-2011 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Drug Discovery
- Organic Chemistry
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Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. / Vijesh, A. M.; Isloor, Arun M.; Telkar, Sandeep; Peethambar, S. K.; Rai, Sankappa; Isloor, Nishitha.
In: European Journal of Medicinal Chemistry, Vol. 46, No. 8, 01.08.2011, p. 3531-3536.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives
AU - Vijesh, A. M.
AU - Isloor, Arun M.
AU - Telkar, Sandeep
AU - Peethambar, S. K.
AU - Rai, Sankappa
AU - Isloor, Nishitha
PY - 2011/8/1
Y1 - 2011/8/1
N2 - In the present study two series of novel imidazole derivatives containing substituted pyrazole moiety (3a-d and 5a-j) were synthesized. The first series were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazones (2a-d) with DMAD and the second series by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes (1a-e) with 1,2-diketones (4a,b) in the presence of ammonium acetate. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for antifungal and antibacterial activities. Among the synthesized compounds, compound 3c was found to be potent antimicrobial agent. The acute oral toxicity study for the compound 3c was carried out and the experimental studies revealed that compound 3c is safe up to 3000 mg/kg and no death of animals were recorded.
AB - In the present study two series of novel imidazole derivatives containing substituted pyrazole moiety (3a-d and 5a-j) were synthesized. The first series were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazones (2a-d) with DMAD and the second series by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes (1a-e) with 1,2-diketones (4a,b) in the presence of ammonium acetate. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for antifungal and antibacterial activities. Among the synthesized compounds, compound 3c was found to be potent antimicrobial agent. The acute oral toxicity study for the compound 3c was carried out and the experimental studies revealed that compound 3c is safe up to 3000 mg/kg and no death of animals were recorded.
UR - http://www.scopus.com/inward/record.url?scp=79958258686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958258686&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2011.05.005
DO - 10.1016/j.ejmech.2011.05.005
M3 - Article
VL - 46
SP - 3531
EP - 3536
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
SN - 0223-5234
IS - 8
ER -