Synthesis, characterization and single crystal studies of 3-cyclopropyl-3, 4-dihydroquinazolin-2(1H)-one

Nitinkumar S. Shetty, Y. F. Nadaf, Dinesh Bilehal, V. Shyamkumar, Santosh L. Gaonkar

Research output: Contribution to journalArticle

Abstract

The paper describes industrially scalable synthesis and single crystal studies of 3-cyclopropyl-3,4-dihydroquinazolin-2(1H)-one 4, a versatile intermediate in the synthesis of number of biologically active compounds. The target compound has been characterized by LC-MS, 1H NMR and IR. The crystal structure analysis shows that the title compound crystallizes in monoclinic class under the space group P 1 21/n 1 with cell parameters, a = 10.273(2) Å, b = 8.3227(19) Å, c = 11.623(3) Å, β = 104.980(3)°, V = 960.0(4) Å3 and Z=4.

Original languageEnglish
Pages (from-to)2707-2712
Number of pages6
JournalOriental Journal of Chemistry
Volume32
Issue number5
DOIs
Publication statusPublished - 2016

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crystal structure
nuclear magnetic resonance
Single crystals
crystal
Crystal structure
Nuclear magnetic resonance
parameter
analysis
Proton Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Environmental Chemistry
  • Biochemistry
  • Drug Discovery

Cite this

@article{d1e8282522b048369616ef91fb27ae44,
title = "Synthesis, characterization and single crystal studies of 3-cyclopropyl-3, 4-dihydroquinazolin-2(1H)-one",
abstract = "The paper describes industrially scalable synthesis and single crystal studies of 3-cyclopropyl-3,4-dihydroquinazolin-2(1H)-one 4, a versatile intermediate in the synthesis of number of biologically active compounds. The target compound has been characterized by LC-MS, 1H NMR and IR. The crystal structure analysis shows that the title compound crystallizes in monoclinic class under the space group P 1 21/n 1 with cell parameters, a = 10.273(2) {\AA}, b = 8.3227(19) {\AA}, c = 11.623(3) {\AA}, β = 104.980(3)°, V = 960.0(4) {\AA}3 and Z=4.",
author = "Shetty, {Nitinkumar S.} and Nadaf, {Y. F.} and Dinesh Bilehal and V. Shyamkumar and Gaonkar, {Santosh L.}",
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Synthesis, characterization and single crystal studies of 3-cyclopropyl-3, 4-dihydroquinazolin-2(1H)-one. / Shetty, Nitinkumar S.; Nadaf, Y. F.; Bilehal, Dinesh; Shyamkumar, V.; Gaonkar, Santosh L.

In: Oriental Journal of Chemistry, Vol. 32, No. 5, 2016, p. 2707-2712.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis, characterization and single crystal studies of 3-cyclopropyl-3, 4-dihydroquinazolin-2(1H)-one

AU - Shetty, Nitinkumar S.

AU - Nadaf, Y. F.

AU - Bilehal, Dinesh

AU - Shyamkumar, V.

AU - Gaonkar, Santosh L.

PY - 2016

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AB - The paper describes industrially scalable synthesis and single crystal studies of 3-cyclopropyl-3,4-dihydroquinazolin-2(1H)-one 4, a versatile intermediate in the synthesis of number of biologically active compounds. The target compound has been characterized by LC-MS, 1H NMR and IR. The crystal structure analysis shows that the title compound crystallizes in monoclinic class under the space group P 1 21/n 1 with cell parameters, a = 10.273(2) Å, b = 8.3227(19) Å, c = 11.623(3) Å, β = 104.980(3)°, V = 960.0(4) Å3 and Z=4.

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