Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles

S. R. Ubaradka, Arun M. Isloor, Prakash Shetty, Prashanth Shetty, Nishitha A. Isloor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N′-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium.

Original languageEnglish
Pages (from-to)1497-1503
Number of pages7
JournalMedicinal Chemistry Research
Volume22
Issue number3
DOIs
Publication statusPublished - 01-03-2013

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Oxadiazoles
Anticonvulsants
Anti-Inflammatory Agents
Diclofenac
Diazepam
Microwaves
Aldehydes
Pharmaceutical Preparations
Amines
Derivatives

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Ubaradka, S. R. ; Isloor, Arun M. ; Shetty, Prakash ; Shetty, Prashanth ; Isloor, Nishitha A. / Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles. In: Medicinal Chemistry Research. 2013 ; Vol. 22, No. 3. pp. 1497-1503.
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Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles. / Ubaradka, S. R.; Isloor, Arun M.; Shetty, Prakash; Shetty, Prashanth; Isloor, Nishitha A.

In: Medicinal Chemistry Research, Vol. 22, No. 3, 01.03.2013, p. 1497-1503.

Research output: Contribution to journalArticle

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