In the current study, an efficient synthesis of new triazole-linked chalcone 3 a-g scaffold was performed by multistep reaction sequence and was screened for their antibacterial activity against Pseudomonas aeruginosa, Escherchia coli, Staphylococcus aureus and Bacillus subtilis. The preliminary result revealed that 3 f exhibited a promising antibacterial activity. Furthermore, 3 f was modified at α, β- unsaturated carbonyl segment to isoxazoline 4 a, pyrimidines 5 a, 6 a-b, pyrazoles 7 a-c and cyanopyridine 8 a. Within the modified compounds 7 b (4-nitro-substituted pyrazole) turn to be more potent against all bacterial strains. In addition compounds, 5 a and 8 a showed promising free radical scavenging activity.
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