Synthesis, Characterization, Antibacterial and Antioxidant Studies of Some Heterocyclic Compounds from Triazole-Linked Chalcone Derivatives

Rangappa Santosh, KS Mukunthan, Saptami U. Kanekar, Gundibasappa K. Nagaraja

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In the current study, an efficient synthesis of new triazole-linked chalcone 3 a-g scaffold was performed by multistep reaction sequence and was screened for their antibacterial activity against Pseudomonas aeruginosa, Escherchia coli, Staphylococcus aureus and Bacillus subtilis. The preliminary result revealed that 3 f exhibited a promising antibacterial activity. Furthermore, 3 f was modified at α, β- unsaturated carbonyl segment to isoxazoline 4 a, pyrimidines 5 a, 6 a-b, pyrazoles 7 a-c and cyanopyridine 8 a. Within the modified compounds 7 b (4-nitro-substituted pyrazole) turn to be more potent against all bacterial strains. In addition compounds, 5 a and 8 a showed promising free radical scavenging activity.

Original languageEnglish
Pages (from-to)6338-6343
Number of pages6
JournalChemistrySelect
Volume3
Issue number23
DOIs
Publication statusPublished - 22-06-2018

Fingerprint

Pyrazoles
Heterocyclic Compounds
Chalcone
Pyrimidines
Triazoles
Scavenging
Bacilli
Scaffolds
Free Radicals
Antioxidants
Derivatives
pyrazole

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Santosh, Rangappa ; Mukunthan, KS ; Kanekar, Saptami U. ; Nagaraja, Gundibasappa K. / Synthesis, Characterization, Antibacterial and Antioxidant Studies of Some Heterocyclic Compounds from Triazole-Linked Chalcone Derivatives. In: ChemistrySelect. 2018 ; Vol. 3, No. 23. pp. 6338-6343.
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Synthesis, Characterization, Antibacterial and Antioxidant Studies of Some Heterocyclic Compounds from Triazole-Linked Chalcone Derivatives. / Santosh, Rangappa; Mukunthan, KS; Kanekar, Saptami U.; Nagaraja, Gundibasappa K.

In: ChemistrySelect, Vol. 3, No. 23, 22.06.2018, p. 6338-6343.

Research output: Contribution to journalArticle

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