Synthesis, characterization, antimicrobial and antioxidant activity of some disubstituted [1,3,4]-oxadiazoles carrying 4-(methylsulfonyl/sulfinyl)benzyl moieties

V. Sumangala, Boja Poojary, N. Chidananda, T. Arulmoli, Shalini Shenoy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Disubstituted [1,3,4]-oxadaiazoles (6a-b), Mannich bases (7a-f) and S-alkylated derivatives (8a-f) have been synthesized from 4-(methylsulfonyl/sulfinyl)phenylaceticacid (3a-b) through a multi-step reaction sequence starting from (4-methylthio)phenylacetonitrile (1). The structures of new compounds were established on the basis of their elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds were screened for their antioxidant, antibacterial and antifungal activity. Some of the derivatives have promising antimicrobial activity.

Original languageEnglish
Pages (from-to)1661-1669
Number of pages9
JournalJournal of Chemical and Pharmaceutical Research
Volume4
Issue number3
Publication statusPublished - 16-04-2012

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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