Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides

B. S. Priya, S. Nanjunda Swamy, M. V. Tejesvi, Basappa, G. Sarala, S. L. Gaonkar, S. Naveen, J. Shashidhara Prasad, K. S. Rangappa

Research output: Contribution to journalArticle

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Abstract

A new class of benzamide derivatives 3a(I-VI) and 3b(I-VI), bearing different bioactive moieties were synthesized and evaluated for their efficacy as antimicrobials in vitro. Compounds 3bVI, 3aII, 3aV, 3bIII, 3aVI, 3bII showed significant antibacterial activity and 3bIII, 3bII, 3aIV, 3bV, 3bVI, 3aI exhibit significant antifungal activity. The title compounds are characterized by spectral and elemental analysis. Compounds 2-methoxy-N-[4-(thiazol-2-yl-sulfamoyl)-phenyl]-benzamide 3aII and 2-(2-(2-ethoxybenzoylamino) phenethyl)-N-(2-ethoxybenzoyl) benzenamine 3bV are characterized by the single crystal X-ray studies. Compound 3aII crystallizes in monoclinic space group P21 and 3bV in triclinic space group P-1. Compounds 3aII and 3bV exhibit both inter and intra molecular hydrogen bonding.

Original languageEnglish
Pages (from-to)1262-1270
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume41
Issue number11
DOIs
Publication statusPublished - 11-2006

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Benzamides
Benzene
Bearings (structural)
X-Rays
X rays
Crystals
Hydrogen Bonding
Spectrum analysis
Hydrogen bonds
Single crystals
Derivatives
Chemical analysis
benzamide

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Priya, B. S. ; Nanjunda Swamy, S. ; Tejesvi, M. V. ; Basappa ; Sarala, G. ; Gaonkar, S. L. ; Naveen, S. ; Shashidhara Prasad, J. ; Rangappa, K. S. / Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides. In: European Journal of Medicinal Chemistry. 2006 ; Vol. 41, No. 11. pp. 1262-1270.
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Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides. / Priya, B. S.; Nanjunda Swamy, S.; Tejesvi, M. V.; Basappa; Sarala, G.; Gaonkar, S. L.; Naveen, S.; Shashidhara Prasad, J.; Rangappa, K. S.

In: European Journal of Medicinal Chemistry, Vol. 41, No. 11, 11.2006, p. 1262-1270.

Research output: Contribution to journalArticle

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AU - Priya, B. S.

AU - Nanjunda Swamy, S.

AU - Tejesvi, M. V.

AU - Basappa,

AU - Sarala, G.

AU - Gaonkar, S. L.

AU - Naveen, S.

AU - Shashidhara Prasad, J.

AU - Rangappa, K. S.

PY - 2006/11

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N2 - A new class of benzamide derivatives 3a(I-VI) and 3b(I-VI), bearing different bioactive moieties were synthesized and evaluated for their efficacy as antimicrobials in vitro. Compounds 3bVI, 3aII, 3aV, 3bIII, 3aVI, 3bII showed significant antibacterial activity and 3bIII, 3bII, 3aIV, 3bV, 3bVI, 3aI exhibit significant antifungal activity. The title compounds are characterized by spectral and elemental analysis. Compounds 2-methoxy-N-[4-(thiazol-2-yl-sulfamoyl)-phenyl]-benzamide 3aII and 2-(2-(2-ethoxybenzoylamino) phenethyl)-N-(2-ethoxybenzoyl) benzenamine 3bV are characterized by the single crystal X-ray studies. Compound 3aII crystallizes in monoclinic space group P21 and 3bV in triclinic space group P-1. Compounds 3aII and 3bV exhibit both inter and intra molecular hydrogen bonding.

AB - A new class of benzamide derivatives 3a(I-VI) and 3b(I-VI), bearing different bioactive moieties were synthesized and evaluated for their efficacy as antimicrobials in vitro. Compounds 3bVI, 3aII, 3aV, 3bIII, 3aVI, 3bII showed significant antibacterial activity and 3bIII, 3bII, 3aIV, 3bV, 3bVI, 3aI exhibit significant antifungal activity. The title compounds are characterized by spectral and elemental analysis. Compounds 2-methoxy-N-[4-(thiazol-2-yl-sulfamoyl)-phenyl]-benzamide 3aII and 2-(2-(2-ethoxybenzoylamino) phenethyl)-N-(2-ethoxybenzoyl) benzenamine 3bV are characterized by the single crystal X-ray studies. Compound 3aII crystallizes in monoclinic space group P21 and 3bV in triclinic space group P-1. Compounds 3aII and 3bV exhibit both inter and intra molecular hydrogen bonding.

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