Synthesis, characterization, DNA binding, and cytotoxic studies of dinuclear complexes of palladium(II) and platinum(II) with 2,2-bipyridine and α,ω-diaminoalkane-N,N′-diacetic acid

Nidhi Jain, R. Mittal, T. S. Srivastava, K. Satyamoorthy, M. P. Chitnis

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    Abstract

    The synthesis of four α,ω-diaminoalkane-N,N′-diacetic acid and their dinuclear 2,2′-bipyridine palladium(II) and platinum(II) complexes of general formula [M2(bipy)2(DADA)] (NO3)2 (where M is Pd(II) or Pt(II), bipy is 2,2′-bipyridine, DADA is dianion of 1,4-diaminobutane-N,N′-diacetic acid (DBDA), 1,6-diaminohexane-N,N′-diacetic acid (DHDA), 1,8-diaminooctane-N,N′-diacetic acid (DODA), or 1,10-diaminodecane-N-N′-diacetic acid (DDDA) has been achieved. They have been characterized by elemental analysis, conductivity measurements, electronic absorption, and infrared and variable temperature 1H NMR spectroscopy. The above eight dinuclear palladium(II) and platinum(II) complexes have been tested for cytotoxicity against P388 lymphocytic leukemia cells. Out of them, [Pt2(bipy)2(DDDA)(NO3)2 and [Pd2(bipy)2(DBDA)](NO3)2 show lower I.D.50 values as compared to cisplatin. The binding of [Pt2(bipy)2(DODA)](NO3)2 and [M2(bipy)2(DHDA)](NO3)2 with calf thymus DNA (deoxyribonucleic acid) has also been studied. [Pt2(bipy)2(DODA/DHDA)](NO3)2 complexes show high positive cooperative binding to DNA, with Hill coefficients of 1.6 to 1.9, respectively, whereas [Pd2(bipy)2(DHDA)](NO3) gives a biphasic Scatchard plot with two different binding sites or with negative cooperativity.

    Original languageEnglish
    Pages (from-to)79-94
    Number of pages16
    JournalJournal of Inorganic Biochemistry
    Volume53
    Issue number2
    DOIs
    Publication statusPublished - 01-02-1994

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    Palladium
    Platinum
    1,6-diaminohexane
    Acids
    DNA
    Lymphoid Leukemia
    Thymus
    Putrescine
    Cytotoxicity
    Thymus Gland
    Cisplatin
    Nuclear magnetic resonance spectroscopy
    Magnetic Resonance Spectroscopy
    Binding Sites
    Infrared radiation

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Inorganic Chemistry

    Cite this

    @article{3d10ba2c1cbf4856a350059d2bf18dee,
    title = "Synthesis, characterization, DNA binding, and cytotoxic studies of dinuclear complexes of palladium(II) and platinum(II) with 2,2-bipyridine and α,ω-diaminoalkane-N,N′-diacetic acid",
    abstract = "The synthesis of four α,ω-diaminoalkane-N,N′-diacetic acid and their dinuclear 2,2′-bipyridine palladium(II) and platinum(II) complexes of general formula [M2(bipy)2(DADA)] (NO3)2 (where M is Pd(II) or Pt(II), bipy is 2,2′-bipyridine, DADA is dianion of 1,4-diaminobutane-N,N′-diacetic acid (DBDA), 1,6-diaminohexane-N,N′-diacetic acid (DHDA), 1,8-diaminooctane-N,N′-diacetic acid (DODA), or 1,10-diaminodecane-N-N′-diacetic acid (DDDA) has been achieved. They have been characterized by elemental analysis, conductivity measurements, electronic absorption, and infrared and variable temperature 1H NMR spectroscopy. The above eight dinuclear palladium(II) and platinum(II) complexes have been tested for cytotoxicity against P388 lymphocytic leukemia cells. Out of them, [Pt2(bipy)2(DDDA)(NO3)2 and [Pd2(bipy)2(DBDA)](NO3)2 show lower I.D.50 values as compared to cisplatin. The binding of [Pt2(bipy)2(DODA)](NO3)2 and [M2(bipy)2(DHDA)](NO3)2 with calf thymus DNA (deoxyribonucleic acid) has also been studied. [Pt2(bipy)2(DODA/DHDA)](NO3)2 complexes show high positive cooperative binding to DNA, with Hill coefficients of 1.6 to 1.9, respectively, whereas [Pd2(bipy)2(DHDA)](NO3) gives a biphasic Scatchard plot with two different binding sites or with negative cooperativity.",
    author = "Nidhi Jain and R. Mittal and Srivastava, {T. S.} and K. Satyamoorthy and Chitnis, {M. P.}",
    year = "1994",
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    T1 - Synthesis, characterization, DNA binding, and cytotoxic studies of dinuclear complexes of palladium(II) and platinum(II) with 2,2-bipyridine and α,ω-diaminoalkane-N,N′-diacetic acid

    AU - Jain, Nidhi

    AU - Mittal, R.

    AU - Srivastava, T. S.

    AU - Satyamoorthy, K.

    AU - Chitnis, M. P.

    PY - 1994/2/1

    Y1 - 1994/2/1

    N2 - The synthesis of four α,ω-diaminoalkane-N,N′-diacetic acid and their dinuclear 2,2′-bipyridine palladium(II) and platinum(II) complexes of general formula [M2(bipy)2(DADA)] (NO3)2 (where M is Pd(II) or Pt(II), bipy is 2,2′-bipyridine, DADA is dianion of 1,4-diaminobutane-N,N′-diacetic acid (DBDA), 1,6-diaminohexane-N,N′-diacetic acid (DHDA), 1,8-diaminooctane-N,N′-diacetic acid (DODA), or 1,10-diaminodecane-N-N′-diacetic acid (DDDA) has been achieved. They have been characterized by elemental analysis, conductivity measurements, electronic absorption, and infrared and variable temperature 1H NMR spectroscopy. The above eight dinuclear palladium(II) and platinum(II) complexes have been tested for cytotoxicity against P388 lymphocytic leukemia cells. Out of them, [Pt2(bipy)2(DDDA)(NO3)2 and [Pd2(bipy)2(DBDA)](NO3)2 show lower I.D.50 values as compared to cisplatin. The binding of [Pt2(bipy)2(DODA)](NO3)2 and [M2(bipy)2(DHDA)](NO3)2 with calf thymus DNA (deoxyribonucleic acid) has also been studied. [Pt2(bipy)2(DODA/DHDA)](NO3)2 complexes show high positive cooperative binding to DNA, with Hill coefficients of 1.6 to 1.9, respectively, whereas [Pd2(bipy)2(DHDA)](NO3) gives a biphasic Scatchard plot with two different binding sites or with negative cooperativity.

    AB - The synthesis of four α,ω-diaminoalkane-N,N′-diacetic acid and their dinuclear 2,2′-bipyridine palladium(II) and platinum(II) complexes of general formula [M2(bipy)2(DADA)] (NO3)2 (where M is Pd(II) or Pt(II), bipy is 2,2′-bipyridine, DADA is dianion of 1,4-diaminobutane-N,N′-diacetic acid (DBDA), 1,6-diaminohexane-N,N′-diacetic acid (DHDA), 1,8-diaminooctane-N,N′-diacetic acid (DODA), or 1,10-diaminodecane-N-N′-diacetic acid (DDDA) has been achieved. They have been characterized by elemental analysis, conductivity measurements, electronic absorption, and infrared and variable temperature 1H NMR spectroscopy. The above eight dinuclear palladium(II) and platinum(II) complexes have been tested for cytotoxicity against P388 lymphocytic leukemia cells. Out of them, [Pt2(bipy)2(DDDA)(NO3)2 and [Pd2(bipy)2(DBDA)](NO3)2 show lower I.D.50 values as compared to cisplatin. The binding of [Pt2(bipy)2(DODA)](NO3)2 and [M2(bipy)2(DHDA)](NO3)2 with calf thymus DNA (deoxyribonucleic acid) has also been studied. [Pt2(bipy)2(DODA/DHDA)](NO3)2 complexes show high positive cooperative binding to DNA, with Hill coefficients of 1.6 to 1.9, respectively, whereas [Pd2(bipy)2(DHDA)](NO3) gives a biphasic Scatchard plot with two different binding sites or with negative cooperativity.

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