Synthesis of 3-[4[4,5-dihydro-5-(substituted aryl)-1H-pyrazol-3-yl]phenyl]sydnones as antiinflammatory and analgesic agents

K. Satyanaryana, M.N.A. Rao

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

3-[4-(3-(Substituted aryl)-1-oxo-2-propenyl]phenyl]sydnones were condensed with hydrazine to yield fifteen 3-[4-(4,5-Dihydro-5-(substituted aryl)-1H-pyrazol-3-yl]phenyl]sydnones. Three compounds have shown antiinflammatory activity in carrageenan induced edema assay in rats and five compounds have shown analgesic activity. In acetic acid-induced writhing assay in mice at 100 mg/kg dose p.o. respectively. Compound 24 exhibited both antiinflammatory and analgesic activity, which appeared to be similar to those produced by the standards phenylbutazone and aspirin. However compound 21 showed more analgesic activity than aspirin (ED 50, 25.0mg/kg, 81.4mg/kg).
Original languageUndefined/Unknown
Pages (from-to)243-248
Number of pages6
JournalIndian Journal of Pharmaceutical Sciences
Volume57
Issue number6
Publication statusPublished - 1995

Cite this

@article{feecbe43dfaa4f2d867560fe37981e52,
title = "Synthesis of 3-[4[4,5-dihydro-5-(substituted aryl)-1H-pyrazol-3-yl]phenyl]sydnones as antiinflammatory and analgesic agents",
abstract = "3-[4-(3-(Substituted aryl)-1-oxo-2-propenyl]phenyl]sydnones were condensed with hydrazine to yield fifteen 3-[4-(4,5-Dihydro-5-(substituted aryl)-1H-pyrazol-3-yl]phenyl]sydnones. Three compounds have shown antiinflammatory activity in carrageenan induced edema assay in rats and five compounds have shown analgesic activity. In acetic acid-induced writhing assay in mice at 100 mg/kg dose p.o. respectively. Compound 24 exhibited both antiinflammatory and analgesic activity, which appeared to be similar to those produced by the standards phenylbutazone and aspirin. However compound 21 showed more analgesic activity than aspirin (ED 50, 25.0mg/kg, 81.4mg/kg).",
author = "K. Satyanaryana and M.N.A. Rao",
note = "cited By 8",
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volume = "57",
pages = "243--248",
journal = "Indian Journal of Pharmaceutical Sciences",
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Synthesis of 3-[4[4,5-dihydro-5-(substituted aryl)-1H-pyrazol-3-yl]phenyl]sydnones as antiinflammatory and analgesic agents. / Satyanaryana, K.; Rao, M.N.A.

In: Indian Journal of Pharmaceutical Sciences, Vol. 57, No. 6, 1995, p. 243-248.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis of 3-[4[4,5-dihydro-5-(substituted aryl)-1H-pyrazol-3-yl]phenyl]sydnones as antiinflammatory and analgesic agents

AU - Satyanaryana, K.

AU - Rao, M.N.A.

N1 - cited By 8

PY - 1995

Y1 - 1995

N2 - 3-[4-(3-(Substituted aryl)-1-oxo-2-propenyl]phenyl]sydnones were condensed with hydrazine to yield fifteen 3-[4-(4,5-Dihydro-5-(substituted aryl)-1H-pyrazol-3-yl]phenyl]sydnones. Three compounds have shown antiinflammatory activity in carrageenan induced edema assay in rats and five compounds have shown analgesic activity. In acetic acid-induced writhing assay in mice at 100 mg/kg dose p.o. respectively. Compound 24 exhibited both antiinflammatory and analgesic activity, which appeared to be similar to those produced by the standards phenylbutazone and aspirin. However compound 21 showed more analgesic activity than aspirin (ED 50, 25.0mg/kg, 81.4mg/kg).

AB - 3-[4-(3-(Substituted aryl)-1-oxo-2-propenyl]phenyl]sydnones were condensed with hydrazine to yield fifteen 3-[4-(4,5-Dihydro-5-(substituted aryl)-1H-pyrazol-3-yl]phenyl]sydnones. Three compounds have shown antiinflammatory activity in carrageenan induced edema assay in rats and five compounds have shown analgesic activity. In acetic acid-induced writhing assay in mice at 100 mg/kg dose p.o. respectively. Compound 24 exhibited both antiinflammatory and analgesic activity, which appeared to be similar to those produced by the standards phenylbutazone and aspirin. However compound 21 showed more analgesic activity than aspirin (ED 50, 25.0mg/kg, 81.4mg/kg).

M3 - Article

VL - 57

SP - 243

EP - 248

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 6

ER -