12 Citations (Scopus)

Abstract

An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC50 below 100 lg/ml, and the same test compounds exhibited 50-100% growth inhibition in Gram-positive bacteria against standard Amoxicillin.

Original languageEnglish
Pages (from-to)1991-1996
Number of pages6
JournalMedicinal Chemistry Research
Volume21
Issue number8
DOIs
Publication statusPublished - 08-2012

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Amoxicillin
Gram-Positive Bacteria
Gram-Negative Bacteria
Inhibitory Concentration 50
Bacteria
Antioxidants
Scavenging
Growth
Substitution reactions

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

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title = "Synthesis of 3-methylflavones and their antioxidant and antibacterial activities",
abstract = "An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC50 below 100 lg/ml, and the same test compounds exhibited 50-100{\%} growth inhibition in Gram-positive bacteria against standard Amoxicillin.",
author = "Jayashree, {B. S.} and Afroze Alam and Yogendra Nayak and {Vijay Kumar}, D.",
year = "2012",
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doi = "10.1007/s00044-011-9725-y",
language = "English",
volume = "21",
pages = "1991--1996",
journal = "Medicinal Chemistry Research",
issn = "1054-2523",
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Synthesis of 3-methylflavones and their antioxidant and antibacterial activities. / Jayashree, B. S.; Alam, Afroze; Nayak, Yogendra; Vijay Kumar, D.

In: Medicinal Chemistry Research, Vol. 21, No. 8, 08.2012, p. 1991-1996.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis of 3-methylflavones and their antioxidant and antibacterial activities

AU - Jayashree, B. S.

AU - Alam, Afroze

AU - Nayak, Yogendra

AU - Vijay Kumar, D.

PY - 2012/8

Y1 - 2012/8

N2 - An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC50 below 100 lg/ml, and the same test compounds exhibited 50-100% growth inhibition in Gram-positive bacteria against standard Amoxicillin.

AB - An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC50 below 100 lg/ml, and the same test compounds exhibited 50-100% growth inhibition in Gram-positive bacteria against standard Amoxicillin.

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DO - 10.1007/s00044-011-9725-y

M3 - Article

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VL - 21

SP - 1991

EP - 1996

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

SN - 1054-2523

IS - 8

ER -