Synthesis of 4-[5-(substituted aryl)-4,5-dihydro-1H-pyrazol-3-yl]-3-phenyl-sydnones as antiinflammatory, antiarthritic and analgesic agents

K. Satyanarayana, M.N.A Rao

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

4-[1-Oxo-3-(substituted aryl)-2-propenyl]-3-phenylsydnones were condensed with hydrazine to yield fourteen 4-[5-(substituted aryl)-4,5-dihydro-1H-pyrazol-3-yl]-3-phenylsydnones. Four compounds have shown antiinflammatory activity in carrageenen-induced edema assay in rats and six compounds have shown analgesic activity in acetic-acid-induced writhing assay in mice at a dosage of 100 mg/kg po. The antiinflammatory activity of these compounds was less than the positive controls phenylbutazone and ibuprofen. However, compound 25 has shown more analgesic activity than aspirin (ED50, 28.3 vs 81.4 mg/kg respectively, po). Two compounds have shown antiarthritic activity in adjuvant-induced arthritis in rats. The ulcerogenicity of active compounds was less than phenylbutazone. © 1995 Elsevier, Paris.
Original languageUndefined/Unknown
Pages (from-to)641-645
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume30
Issue number7-8
DOIs
Publication statusPublished - 1995

Cite this

@article{ba9108e6fd9b48b48a9e6d05b8d4eddf,
title = "Synthesis of 4-[5-(substituted aryl)-4,5-dihydro-1H-pyrazol-3-yl]-3-phenyl-sydnones as antiinflammatory, antiarthritic and analgesic agents",
abstract = "4-[1-Oxo-3-(substituted aryl)-2-propenyl]-3-phenylsydnones were condensed with hydrazine to yield fourteen 4-[5-(substituted aryl)-4,5-dihydro-1H-pyrazol-3-yl]-3-phenylsydnones. Four compounds have shown antiinflammatory activity in carrageenen-induced edema assay in rats and six compounds have shown analgesic activity in acetic-acid-induced writhing assay in mice at a dosage of 100 mg/kg po. The antiinflammatory activity of these compounds was less than the positive controls phenylbutazone and ibuprofen. However, compound 25 has shown more analgesic activity than aspirin (ED50, 28.3 vs 81.4 mg/kg respectively, po). Two compounds have shown antiarthritic activity in adjuvant-induced arthritis in rats. The ulcerogenicity of active compounds was less than phenylbutazone. {\circledC} 1995 Elsevier, Paris.",
author = "K. Satyanarayana and M.N.A Rao",
note = "cited By 24",
year = "1995",
doi = "10.1016/0223-5234(96)88280-8",
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pages = "641--645",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
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Synthesis of 4-[5-(substituted aryl)-4,5-dihydro-1H-pyrazol-3-yl]-3-phenyl-sydnones as antiinflammatory, antiarthritic and analgesic agents. / Satyanarayana, K.; Rao, M.N.A.

In: European Journal of Medicinal Chemistry, Vol. 30, No. 7-8, 1995, p. 641-645.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis of 4-[5-(substituted aryl)-4,5-dihydro-1H-pyrazol-3-yl]-3-phenyl-sydnones as antiinflammatory, antiarthritic and analgesic agents

AU - Satyanarayana, K.

AU - Rao, M.N.A

N1 - cited By 24

PY - 1995

Y1 - 1995

N2 - 4-[1-Oxo-3-(substituted aryl)-2-propenyl]-3-phenylsydnones were condensed with hydrazine to yield fourteen 4-[5-(substituted aryl)-4,5-dihydro-1H-pyrazol-3-yl]-3-phenylsydnones. Four compounds have shown antiinflammatory activity in carrageenen-induced edema assay in rats and six compounds have shown analgesic activity in acetic-acid-induced writhing assay in mice at a dosage of 100 mg/kg po. The antiinflammatory activity of these compounds was less than the positive controls phenylbutazone and ibuprofen. However, compound 25 has shown more analgesic activity than aspirin (ED50, 28.3 vs 81.4 mg/kg respectively, po). Two compounds have shown antiarthritic activity in adjuvant-induced arthritis in rats. The ulcerogenicity of active compounds was less than phenylbutazone. © 1995 Elsevier, Paris.

AB - 4-[1-Oxo-3-(substituted aryl)-2-propenyl]-3-phenylsydnones were condensed with hydrazine to yield fourteen 4-[5-(substituted aryl)-4,5-dihydro-1H-pyrazol-3-yl]-3-phenylsydnones. Four compounds have shown antiinflammatory activity in carrageenen-induced edema assay in rats and six compounds have shown analgesic activity in acetic-acid-induced writhing assay in mice at a dosage of 100 mg/kg po. The antiinflammatory activity of these compounds was less than the positive controls phenylbutazone and ibuprofen. However, compound 25 has shown more analgesic activity than aspirin (ED50, 28.3 vs 81.4 mg/kg respectively, po). Two compounds have shown antiarthritic activity in adjuvant-induced arthritis in rats. The ulcerogenicity of active compounds was less than phenylbutazone. © 1995 Elsevier, Paris.

U2 - 10.1016/0223-5234(96)88280-8

DO - 10.1016/0223-5234(96)88280-8

M3 - Article

VL - 30

SP - 641

EP - 645

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

IS - 7-8

ER -