Spiro 1,2,4-trioxane are synthetic derivative of artemisinin (1,2,4-trioxane is supposed to be a pharmacophore of artemisinin) which is a well known antimalarial drug from leaves of Artemisia annua found in China. Spiro 1,2,4-trioxane substituted with admantane and its 4 different derivatives were synthesized using well standardized method. These compounds were purified by simple column chromatography and successfully analyzed using 'H NMR, IR and FAB-MS techniques.
|Number of pages||7|
|Journal||Asian Journal of Chemistry|
|Publication status||Published - 2009|
Kumar, L., Kaushik, N., Malik, A., & Kumar, P. (2009). Synthesis of admantane substituted spiro 1,2,4-trioxanes using simple and cheap starting material. Asian Journal of Chemistry, 21(5), 3540-3546. https://www.scopus.com/inward/record.uri?eid=2-s2.0-63849203094&partnerID=40&md5=1e3bc4cbff69474b485f7a02919ad502