Synthesis of admantane substituted spiro 1,2,4-trioxanes using simple and cheap starting material

L. Kumar, N. Kaushik, A. Malik, P. Kumar

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Abstract

Spiro 1,2,4-trioxane are synthetic derivative of artemisinin (1,2,4-trioxane is supposed to be a pharmacophore of artemisinin) which is a well known antimalarial drug from leaves of Artemisia annua found in China. Spiro 1,2,4-trioxane substituted with admantane and its 4 different derivatives were synthesized using well standardized method. These compounds were purified by simple column chromatography and successfully analyzed using 'H NMR, IR and FAB-MS techniques.
Original languageEnglish
Pages (from-to)3540-3546
Number of pages7
JournalAsian Journal of Chemistry
Volume21
Issue number5
Publication statusPublished - 2009
Externally publishedYes

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