Synthesis of new 4[4-(4-nitrophenoxy)phenyl]-5-substituted-2H-1,2,4-triazole-3-thiones and their evaluation as anthelmintics

B. Namratha, Dinesh Bilehal, V. Shyamkumar, Santosh L. Gaonkar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A library of novel 4-[4-(4-nitrophenoxy)phenyl]-5-substituted-2H-1,2,4-triazole-3-thiones containing different substituents at the 5-position is synthesized. The mechanochemical treatment is followed to synthesize target compounds 8 (a-p), and the yields are compared by both the grinding method and the conventional method. The structure of the intermediate, isothiocyanato-4-(4-nitrophenoxy)benzene 6, is analyzed by single crystal X-ray studies. The title compounds are characterized by spectral and elemental analyses and further evaluated for their efficacy as anthelmintics in vitro. Compounds 8c, 8j, 8k, 8l, and 8m exhibit significant anthelmintic activity.

Original languageEnglish
Pages (from-to)1885-1897
Number of pages13
JournalResearch on Chemical Intermediates
Volume42
Issue number3
DOIs
Publication statusPublished - 01-03-2016

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Thiones
Anthelmintics
Benzene
Single crystals
X rays
1,2,4-triazole

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

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abstract = "A library of novel 4-[4-(4-nitrophenoxy)phenyl]-5-substituted-2H-1,2,4-triazole-3-thiones containing different substituents at the 5-position is synthesized. The mechanochemical treatment is followed to synthesize target compounds 8 (a-p), and the yields are compared by both the grinding method and the conventional method. The structure of the intermediate, isothiocyanato-4-(4-nitrophenoxy)benzene 6, is analyzed by single crystal X-ray studies. The title compounds are characterized by spectral and elemental analyses and further evaluated for their efficacy as anthelmintics in vitro. Compounds 8c, 8j, 8k, 8l, and 8m exhibit significant anthelmintic activity.",
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Synthesis of new 4[4-(4-nitrophenoxy)phenyl]-5-substituted-2H-1,2,4-triazole-3-thiones and their evaluation as anthelmintics. / Namratha, B.; Bilehal, Dinesh; Shyamkumar, V.; Gaonkar, Santosh L.

In: Research on Chemical Intermediates, Vol. 42, No. 3, 01.03.2016, p. 1885-1897.

Research output: Contribution to journalArticle

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AU - Gaonkar, Santosh L.

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