Synthesis of new biologically active arylfuranylmethyltriazinones and their antibacterial activity studies

B. Shivarama Holla, M. K. Shivananda, B. Veerendra, K. Subrahmanya Bhat

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In view of the pharmacological activities of 1,2,4-triazinones, a series of 4-amino-6-arylfuranylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones 7 have been synthesized by refluxing pyruvic acids 5 in ethanol with thiocarbohydrazide 6 on a steam-bath. The structures of 7 are confirmed by elemental analysis, IR, NMR and mass spectral data. Also, these compounds 7 have been screened for antibacterial activities against E. coli, S.aureus, P. aeruginosa and G. bacillus. Their MIC values are determined. The results indicate that among the compounds tested, compounds 7a and 7c carrying p-chloro and p-bromo substituents show excellent antibacterial activity against all the bacteria tested. It is concluded that compounds 7a, 7c, 7d and 7f may prove to be promising antibacterial agents.

Original languageEnglish
Pages (from-to)2649-2651
Number of pages3
JournalIndian Journal of Chemistry - Section B Organic and Medicinal Chemistry
Volume42
Issue number10
Publication statusPublished - 10-2003

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Steam Bath
Steam
Bacilli
Pyruvic Acid
Escherichia coli
Bacillus
Bacteria
Ethanol
Nuclear magnetic resonance
Pharmacology
Anti-Bacterial Agents
Chemical analysis
thiocarbohydrazide

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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abstract = "In view of the pharmacological activities of 1,2,4-triazinones, a series of 4-amino-6-arylfuranylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones 7 have been synthesized by refluxing pyruvic acids 5 in ethanol with thiocarbohydrazide 6 on a steam-bath. The structures of 7 are confirmed by elemental analysis, IR, NMR and mass spectral data. Also, these compounds 7 have been screened for antibacterial activities against E. coli, S.aureus, P. aeruginosa and G. bacillus. Their MIC values are determined. The results indicate that among the compounds tested, compounds 7a and 7c carrying p-chloro and p-bromo substituents show excellent antibacterial activity against all the bacteria tested. It is concluded that compounds 7a, 7c, 7d and 7f may prove to be promising antibacterial agents.",
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Synthesis of new biologically active arylfuranylmethyltriazinones and their antibacterial activity studies. / Holla, B. Shivarama; Shivananda, M. K.; Veerendra, B.; Bhat, K. Subrahmanya.

In: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, Vol. 42, No. 10, 10.2003, p. 2649-2651.

Research output: Contribution to journalArticle

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T1 - Synthesis of new biologically active arylfuranylmethyltriazinones and their antibacterial activity studies

AU - Holla, B. Shivarama

AU - Shivananda, M. K.

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AU - Bhat, K. Subrahmanya

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AB - In view of the pharmacological activities of 1,2,4-triazinones, a series of 4-amino-6-arylfuranylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones 7 have been synthesized by refluxing pyruvic acids 5 in ethanol with thiocarbohydrazide 6 on a steam-bath. The structures of 7 are confirmed by elemental analysis, IR, NMR and mass spectral data. Also, these compounds 7 have been screened for antibacterial activities against E. coli, S.aureus, P. aeruginosa and G. bacillus. Their MIC values are determined. The results indicate that among the compounds tested, compounds 7a and 7c carrying p-chloro and p-bromo substituents show excellent antibacterial activity against all the bacteria tested. It is concluded that compounds 7a, 7c, 7d and 7f may prove to be promising antibacterial agents.

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