Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero Diels-Alder reaction and evaluation of antimicrobial activity

M. K. Manjula, K. M.L. Rai, S. L. Gaonkar, K. A. Raveesha, S. Satish

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A new series of 5,6-dihydro-4H-1,2-oxazines were synthesized via hetero Diels-Alder reaction of α-nitrosoolefins with alkenes. α-Nitrosoolefins were generated from ketoximes by the action of chloramine-T. The newly synthesized compounds were characterized with IR, NMR, elemental analysis and screened for their antimicrobial activity; they exhibited excellent antimicrobial activity. The minimal inhibitory concentration of the compounds was in the range of 10-35 μg ml-1 for bacteria and 10-40 μg ml-1 for fungi.

Original languageEnglish
Pages (from-to)280-288
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume44
Issue number1
DOIs
Publication statusPublished - 01-2009

Fingerprint

Oxazines
Oximes
Cycloaddition Reaction
Alkenes
Fungi
Bacteria
Nuclear magnetic resonance
Chemical analysis
chloramine-T
oxazine 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

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abstract = "A new series of 5,6-dihydro-4H-1,2-oxazines were synthesized via hetero Diels-Alder reaction of α-nitrosoolefins with alkenes. α-Nitrosoolefins were generated from ketoximes by the action of chloramine-T. The newly synthesized compounds were characterized with IR, NMR, elemental analysis and screened for their antimicrobial activity; they exhibited excellent antimicrobial activity. The minimal inhibitory concentration of the compounds was in the range of 10-35 μg ml-1 for bacteria and 10-40 μg ml-1 for fungi.",
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Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero Diels-Alder reaction and evaluation of antimicrobial activity. / Manjula, M. K.; Rai, K. M.L.; Gaonkar, S. L.; Raveesha, K. A.; Satish, S.

In: European Journal of Medicinal Chemistry, Vol. 44, No. 1, 01.2009, p. 280-288.

Research output: Contribution to journalArticle

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AU - Raveesha, K. A.

AU - Satish, S.

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