Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero Diels-Alder reaction and evaluation of antimicrobial activity

M. K. Manjula, K. M.L. Rai, S. L. Gaonkar, K. A. Raveesha, S. Satish

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A new series of 5,6-dihydro-4H-1,2-oxazines were synthesized via hetero Diels-Alder reaction of α-nitrosoolefins with alkenes. α-Nitrosoolefins were generated from ketoximes by the action of chloramine-T. The newly synthesized compounds were characterized with IR, NMR, elemental analysis and screened for their antimicrobial activity; they exhibited excellent antimicrobial activity. The minimal inhibitory concentration of the compounds was in the range of 10-35 μg ml-1 for bacteria and 10-40 μg ml-1 for fungi.

Original languageEnglish
Pages (from-to)280-288
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Issue number1
Publication statusPublished - 01-2009


All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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