Synthesis of novel hydroxypropyl methyl cellulose acrylate - A novel superdisintegrating agent for pharmaceutical applications

S. Roy, K. Pal, G. Thakur, B. Prabhakar

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The current study deals with the synthesis of novel hydroxypropyl methyl cellulose acrylate (HPMCAA) by the process of esterification of hydroxypropyl methyl cellulose (HPMC) and acryloyl chloride. The polymers were characterized by Fourier transform infrared (FTIR) spectrophotometry, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and hemocompatibility studies. The microstructures of the HPMC and HPMCAA powders were studied under a scanning electron microscope. The powders were used as an excipient for the preparation of lactose tablets and their composition was varied from 2 to 8% (w/w) of the total tablet weight. Disintegration studies for the tablets were carried out. The results indicated formation of a new product, HPMCAA, having properties different from HPMC. HPMCAA was found to be hemocompatible in nature. Disintegration tests indicated that HPMCAA could be tried as a superdisintegrating agent.

Original languageEnglish
Pages (from-to)1477-1481
Number of pages5
JournalMaterials and Manufacturing Processes
Volume25
Issue number12
DOIs
Publication statusPublished - 01-12-2010

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Drug products
Cellulose
Pharmaceutical Preparations
Tablets
Disintegration
Powders
Hypromellose Derivatives
acrylic acid
Spectrophotometry
Esterification
Excipients
Lactose
Differential scanning calorimetry
Fourier transforms
Electron microscopes
Polymers
Infrared radiation
Scanning
X ray diffraction
Microstructure

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Industrial and Manufacturing Engineering

Cite this

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Synthesis of novel hydroxypropyl methyl cellulose acrylate - A novel superdisintegrating agent for pharmaceutical applications. / Roy, S.; Pal, K.; Thakur, G.; Prabhakar, B.

In: Materials and Manufacturing Processes, Vol. 25, No. 12, 01.12.2010, p. 1477-1481.

Research output: Contribution to journalArticle

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