Synthesis of novel indolyl-pyrimidine antiinflammatory, antioxidant and antibacterial agents

S. Panda, P.V.R. Chowdary

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A number of chalcones were synthesized by reacting indole-3-aldehyde, prepared by Vilsemeir Haack reaction with 4-substituted acetophenone in NaOH solution in ethanol. These chalcones were immediately reacted with urea, thiourea and guanidine hydrochloride in presence of concentrated hydrochloric acid as reagent to obtain the corresponding hydroxy, thio and amino pyrimidines. The synthesized heterocyclics were characterized on the basis of physical, chemical tests and spectroscopic data and were tested for the acute antiinflammatory activity, antioxidant, antibacterial activity using carragenan-induced rat paw oedema method, DPPH (diphenylpicrylhydrazyl) radical scavenging method and cup plate method using Muller-Hinton agar media respectively. Evaluation of the compounds revealed remarkable antiinflammatory activity reflected by their ability to reduce the carragenan-induced inflammation in rats, appreciable antioxidant activity and also antibacterial activity was observed.
Original languageEnglish
Pages (from-to)208-215
Number of pages8
JournalIndian Journal of Pharmaceutical Sciences
Volume70
Issue number2
DOIs
Publication statusPublished - 2008

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