Synthesis of some amino acids incorporated 4(3H)-quinazolinones as possible antiherpes viral agents

S. N. Meyyanathan, K. E. Murali, H. R. Chandrashekhar, A. Godavarthi, S. A. Dhanaraj, P. Vijayan, B. Suresh

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6 Citations (Scopus)

Abstract

Anthranilic acid was refluxed with acetic anhydride and sodium acetate to form N-acetyl anthranilic acid. The acetylated product was cyclised to 4-(2-methy|-4-oxo-4H-quinazolin-3-yl)-benzoic acid (I) with p-aminobenzoic acid in the presence of phosphorous pentoxide and glacial acetic acid. The quinazolinone derivative so formed on reaction with thionyl chloride in the presence of 1,4-dioxan as solvent form the chloro derivative (II) which was then treated with different amino acids gave the title compounds, 4-(2-methyl-4oxo-4H-quinazolin-3yl)-benzoyl aminoacid derivatives (1-5). All the intermediates and title compounds were characterized by physical, chemical, analytical and spectral data. All the title compounds have been screened for their invitro cytotoxic and antiviral activities. Compound 5 showed potent antiviral activity.

Original languageEnglish
Pages (from-to)497-502
Number of pages6
JournalIndian Drugs
Volume43
Issue number6
Publication statusPublished - 01-06-2006

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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    Meyyanathan, S. N., Murali, K. E., Chandrashekhar, H. R., Godavarthi, A., Dhanaraj, S. A., Vijayan, P., & Suresh, B. (2006). Synthesis of some amino acids incorporated 4(3H)-quinazolinones as possible antiherpes viral agents. Indian Drugs, 43(6), 497-502.