Synthesis of some new 1,2,4-triazolo[3,4-b]-thiadiazole derivatives as possible anticancer agents

K. Subrahmanya Bhat, D. Jagadeesh Prasad, Boja Poojary, B. Shivarama Holla

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

3-Substituted-4-amino-5-mercapto-1,2,4-triazoles are versatile synthons for constructing various biologically active heterocycles. Their cyclization with carboxylic acids gives fused five-membered derivatives, whereas with α-bromoketones gives a six-membered heterocycle. In this article we report the synthesis of a series of 1,2,4-triazolo[3,4-b]thiadiazoles 5 starting from 4-amino-3-substituted-5-mercapto-1,2,4-triazoles 3 and fluorobenzoic acids 4 using phosphorous oxychloride as cyclizing agent. Fourteen of the newly synthesized compounds were screened for anticancer properties. Four among them showed in vitro anticancer activity.

Original languageEnglish
Pages (from-to)1595-1603
Number of pages9
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Volume179
Issue number8
DOIs
Publication statusPublished - 08-2004

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Thiadiazoles
Cyclization
Carboxylic Acids
Antineoplastic Agents
Derivatives
3-amino-5-mercapto-1,2,4-triazole
1,2,4-triazole
In Vitro Techniques
3-fluorobenzoic acid

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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abstract = "3-Substituted-4-amino-5-mercapto-1,2,4-triazoles are versatile synthons for constructing various biologically active heterocycles. Their cyclization with carboxylic acids gives fused five-membered derivatives, whereas with α-bromoketones gives a six-membered heterocycle. In this article we report the synthesis of a series of 1,2,4-triazolo[3,4-b]thiadiazoles 5 starting from 4-amino-3-substituted-5-mercapto-1,2,4-triazoles 3 and fluorobenzoic acids 4 using phosphorous oxychloride as cyclizing agent. Fourteen of the newly synthesized compounds were screened for anticancer properties. Four among them showed in vitro anticancer activity.",
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Synthesis of some new 1,2,4-triazolo[3,4-b]-thiadiazole derivatives as possible anticancer agents. / Subrahmanya Bhat, K.; Jagadeesh Prasad, D.; Poojary, Boja; Shivarama Holla, B.

In: Phosphorus, Sulfur and Silicon and the Related Elements, Vol. 179, No. 8, 08.2004, p. 1595-1603.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis of some new 1,2,4-triazolo[3,4-b]-thiadiazole derivatives as possible anticancer agents

AU - Subrahmanya Bhat, K.

AU - Jagadeesh Prasad, D.

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AU - Shivarama Holla, B.

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AB - 3-Substituted-4-amino-5-mercapto-1,2,4-triazoles are versatile synthons for constructing various biologically active heterocycles. Their cyclization with carboxylic acids gives fused five-membered derivatives, whereas with α-bromoketones gives a six-membered heterocycle. In this article we report the synthesis of a series of 1,2,4-triazolo[3,4-b]thiadiazoles 5 starting from 4-amino-3-substituted-5-mercapto-1,2,4-triazoles 3 and fluorobenzoic acids 4 using phosphorous oxychloride as cyclizing agent. Fourteen of the newly synthesized compounds were screened for anticancer properties. Four among them showed in vitro anticancer activity.

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