Synthesis of some new biologically active bis-(thiadiazolotriazines) and bis-(thiadiazolotriazinyl) alkanes

B. Shivarama Holla, Richard Gonsalves, B. Sooryanarayana Rao, Shalini Shenoy, H. N. Gopalakrishna

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

4-Amino-3-mercapto-1,2,4-triazin-5(4H)-ones (1) were condensed with dicarboxylic acids 2 to yield bis-(4-oxo-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-7-yl)alkanes (3b-d,f-h,j-l,n-p) and bis-thiadiazolotriazines (3a,e,i,m). All the newly synthesised compounds were characterised by analytical, IR, NMR and mass spectral studies. Some of the newly synthesised compounds were screened for their antibacterial and antifungal properties. Among the tested compounds, compound 7,7′-(1,4-butanediyl)-bis-(3-t-butyl-4-oxo-4H-1,3,4-thia- diazolo[2,3-c]-1,2,4-triazine (3p) exhibited highest degree of antifungal activity.

Original languageEnglish
Pages (from-to)899-903
Number of pages5
JournalFarmaco
Volume56
Issue number12
DOIs
Publication statusPublished - 01-12-2001

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Dicarboxylic Acids
Alkanes
Nuclear magnetic resonance
1,2,4-triazine

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmaceutical Science

Cite this

Shivarama Holla, B., Gonsalves, R., Sooryanarayana Rao, B., Shenoy, S., & Gopalakrishna, H. N. (2001). Synthesis of some new biologically active bis-(thiadiazolotriazines) and bis-(thiadiazolotriazinyl) alkanes. Farmaco, 56(12), 899-903. https://doi.org/10.1016/S0014-827X(01)01119-3
Shivarama Holla, B. ; Gonsalves, Richard ; Sooryanarayana Rao, B. ; Shenoy, Shalini ; Gopalakrishna, H. N. / Synthesis of some new biologically active bis-(thiadiazolotriazines) and bis-(thiadiazolotriazinyl) alkanes. In: Farmaco. 2001 ; Vol. 56, No. 12. pp. 899-903.
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Shivarama Holla, B, Gonsalves, R, Sooryanarayana Rao, B, Shenoy, S & Gopalakrishna, HN 2001, 'Synthesis of some new biologically active bis-(thiadiazolotriazines) and bis-(thiadiazolotriazinyl) alkanes', Farmaco, vol. 56, no. 12, pp. 899-903. https://doi.org/10.1016/S0014-827X(01)01119-3

Synthesis of some new biologically active bis-(thiadiazolotriazines) and bis-(thiadiazolotriazinyl) alkanes. / Shivarama Holla, B.; Gonsalves, Richard; Sooryanarayana Rao, B.; Shenoy, Shalini; Gopalakrishna, H. N.

In: Farmaco, Vol. 56, No. 12, 01.12.2001, p. 899-903.

Research output: Contribution to journalArticle

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AU - Shenoy, Shalini

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Shivarama Holla B, Gonsalves R, Sooryanarayana Rao B, Shenoy S, Gopalakrishna HN. Synthesis of some new biologically active bis-(thiadiazolotriazines) and bis-(thiadiazolotriazinyl) alkanes. Farmaco. 2001 Dec 1;56(12):899-903. https://doi.org/10.1016/S0014-827X(01)01119-3