4-Amino-3-mercapto-1,2,4-triazin-5(4H)-ones (1) were condensed with dicarboxylic acids 2 to yield bis-(4-oxo-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-7-yl)alkanes (3b-d,f-h,j-l,n-p) and bis-thiadiazolotriazines (3a,e,i,m). All the newly synthesised compounds were characterised by analytical, IR, NMR and mass spectral studies. Some of the newly synthesised compounds were screened for their antibacterial and antifungal properties. Among the tested compounds, compound 7,7′-(1,4-butanediyl)-bis-(3-t-butyl-4-oxo-4H-1,3,4-thia- diazolo[2,3-c]-1,2,4-triazine (3p) exhibited highest degree of antifungal activity.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Pharmaceutical Science