Synthesis of some new biologically active bis-(thiadiazolotriazines) and bis-(thiadiazolotriazinyl) alkanes

B. Shivarama Holla, Richard Gonsalves, B. Sooryanarayana Rao, Shalini Shenoy, H. N. Gopalakrishna

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Abstract

4-Amino-3-mercapto-1,2,4-triazin-5(4H)-ones (1) were condensed with dicarboxylic acids 2 to yield bis-(4-oxo-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-7-yl)alkanes (3b-d,f-h,j-l,n-p) and bis-thiadiazolotriazines (3a,e,i,m). All the newly synthesised compounds were characterised by analytical, IR, NMR and mass spectral studies. Some of the newly synthesised compounds were screened for their antibacterial and antifungal properties. Among the tested compounds, compound 7,7′-(1,4-butanediyl)-bis-(3-t-butyl-4-oxo-4H-1,3,4-thia- diazolo[2,3-c]-1,2,4-triazine (3p) exhibited highest degree of antifungal activity.

Original languageEnglish
Pages (from-to)899-903
Number of pages5
JournalFarmaco
Volume56
Issue number12
DOIs
Publication statusPublished - 01-12-2001

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All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmaceutical Science

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