Synthesis of some new biologically active thiadiazolotriazinones - Part II

B. Shivarama Holla, B. K. Sarojini, K. Shridhara, Georgy Antony

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Abstract

4-Amino-6-phenyl/methyl-3-mercapto-1,2,4-triazin-5(4H)-ones (1) are condensed with an aromatic carboxylic acid, aryloxyacetic acid or anilinoacetic acid (2), to yield 7-substituted-3-phenyl/methyl-4H-1,3,4-thiadiazolo-[2,3-c]-1,2,4-triazin-4-ones (3). Phosphorus oxychloride is used as a cyclizing agent. All the synthesized compounds are screened for their antibacterial activities against S. aureus, E. coli, P. aeruginosa and G. bacillus.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalFarmaco
Volume54
Issue number3
DOIs
Publication statusPublished - 31-03-1999
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmaceutical Science

Cite this

Holla, B. S., Sarojini, B. K., Shridhara, K., & Antony, G. (1999). Synthesis of some new biologically active thiadiazolotriazinones - Part II. Farmaco, 54(3), 149-151. https://doi.org/10.1016/S0014-827X(99)00008-7