Abstract
4-Amino-6-phenyl/methyl-3-mercapto-1,2,4-triazin-5(4H)-ones (1) are condensed with an aromatic carboxylic acid, aryloxyacetic acid or anilinoacetic acid (2), to yield 7-substituted-3-phenyl/methyl-4H-1,3,4-thiadiazolo-[2,3-c]-1,2,4-triazin-4-ones (3). Phosphorus oxychloride is used as a cyclizing agent. All the synthesized compounds are screened for their antibacterial activities against S. aureus, E. coli, P. aeruginosa and G. bacillus.
| Original language | English |
|---|---|
| Pages (from-to) | 149-151 |
| Number of pages | 3 |
| Journal | Farmaco |
| Volume | 54 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 31-03-1999 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Pharmaceutical Science
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Holla, B. S., Sarojini, B. K., Shridhara, K., & Antony, G. (1999). Synthesis of some new biologically active thiadiazolotriazinones - Part II. Farmaco, 54(3), 149-151. https://doi.org/10.1016/S0014-827X(99)00008-7