Synthesis of some new fluorine containing thiadiazolotriazinones as potential antibacterial agents

B. Shivarama Holla, K. Subrahmanya Bhat, N. Suchetha Shetty

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

2,4-dichloro-5-fluorophenyl, 4-fluoro-3-(Phenoxy)phenyl, 4-fluorophenyl groups are known pharmacophores and can be used in the synthesis of new biologically active molecules. Therefore, 4-amino-6-arylmethyl-3-mercapto-1,2,4- triazin5(4H)-ones 1 are condensed with 3-phenoxy-4-fluoro-benzoic acid, 2,4-dichloro-5-fluorobenzoic acid, and 4-fluorobenzoic acid 2 to give 7-substituted-3-arylmethyl-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-ones 3. Phosphorous oxychloride was used as cyclizing agent. All the newly synthesized compounds 3a-l was screened for their antibacterial activities. Most of them showed promising activity in the range of 10 μg/mL concentrations.

Original languageEnglish
Pages (from-to)2193-2199
Number of pages7
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Volume178
Issue number10
Publication statusPublished - 10-2003

Fingerprint

Benzoic Acid
Fluorine
Anti-Bacterial Agents
Molecules
Acids
4-fluorobenzoic acid

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

@article{56d6d46d47f04414a2660686dd04def7,
title = "Synthesis of some new fluorine containing thiadiazolotriazinones as potential antibacterial agents",
abstract = "2,4-dichloro-5-fluorophenyl, 4-fluoro-3-(Phenoxy)phenyl, 4-fluorophenyl groups are known pharmacophores and can be used in the synthesis of new biologically active molecules. Therefore, 4-amino-6-arylmethyl-3-mercapto-1,2,4- triazin5(4H)-ones 1 are condensed with 3-phenoxy-4-fluoro-benzoic acid, 2,4-dichloro-5-fluorobenzoic acid, and 4-fluorobenzoic acid 2 to give 7-substituted-3-arylmethyl-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-ones 3. Phosphorous oxychloride was used as cyclizing agent. All the newly synthesized compounds 3a-l was screened for their antibacterial activities. Most of them showed promising activity in the range of 10 μg/mL concentrations.",
author = "Holla, {B. Shivarama} and Bhat, {K. Subrahmanya} and Shetty, {N. Suchetha}",
year = "2003",
month = "10",
language = "English",
volume = "178",
pages = "2193--2199",
journal = "Phosphorus, Sulfur and Silicon and the Related Elements",
issn = "1042-6507",
publisher = "Taylor and Francis Ltd.",
number = "10",

}

Synthesis of some new fluorine containing thiadiazolotriazinones as potential antibacterial agents. / Holla, B. Shivarama; Bhat, K. Subrahmanya; Shetty, N. Suchetha.

In: Phosphorus, Sulfur and Silicon and the Related Elements, Vol. 178, No. 10, 10.2003, p. 2193-2199.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis of some new fluorine containing thiadiazolotriazinones as potential antibacterial agents

AU - Holla, B. Shivarama

AU - Bhat, K. Subrahmanya

AU - Shetty, N. Suchetha

PY - 2003/10

Y1 - 2003/10

N2 - 2,4-dichloro-5-fluorophenyl, 4-fluoro-3-(Phenoxy)phenyl, 4-fluorophenyl groups are known pharmacophores and can be used in the synthesis of new biologically active molecules. Therefore, 4-amino-6-arylmethyl-3-mercapto-1,2,4- triazin5(4H)-ones 1 are condensed with 3-phenoxy-4-fluoro-benzoic acid, 2,4-dichloro-5-fluorobenzoic acid, and 4-fluorobenzoic acid 2 to give 7-substituted-3-arylmethyl-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-ones 3. Phosphorous oxychloride was used as cyclizing agent. All the newly synthesized compounds 3a-l was screened for their antibacterial activities. Most of them showed promising activity in the range of 10 μg/mL concentrations.

AB - 2,4-dichloro-5-fluorophenyl, 4-fluoro-3-(Phenoxy)phenyl, 4-fluorophenyl groups are known pharmacophores and can be used in the synthesis of new biologically active molecules. Therefore, 4-amino-6-arylmethyl-3-mercapto-1,2,4- triazin5(4H)-ones 1 are condensed with 3-phenoxy-4-fluoro-benzoic acid, 2,4-dichloro-5-fluorobenzoic acid, and 4-fluorobenzoic acid 2 to give 7-substituted-3-arylmethyl-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-ones 3. Phosphorous oxychloride was used as cyclizing agent. All the newly synthesized compounds 3a-l was screened for their antibacterial activities. Most of them showed promising activity in the range of 10 μg/mL concentrations.

UR - http://www.scopus.com/inward/record.url?scp=0345724733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345724733&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0345724733

VL - 178

SP - 2193

EP - 2199

JO - Phosphorus, Sulfur and Silicon and the Related Elements

JF - Phosphorus, Sulfur and Silicon and the Related Elements

SN - 1042-6507

IS - 10

ER -