Synthesis of some new fluorine containing thiadiazolotriazinones as potential antibacterial agents

B. Shivarama Holla, K. Subrahmanya Bhat, N. Suchetha Shetty

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7 Citations (Scopus)


2,4-dichloro-5-fluorophenyl, 4-fluoro-3-(Phenoxy)phenyl, 4-fluorophenyl groups are known pharmacophores and can be used in the synthesis of new biologically active molecules. Therefore, 4-amino-6-arylmethyl-3-mercapto-1,2,4- triazin5(4H)-ones 1 are condensed with 3-phenoxy-4-fluoro-benzoic acid, 2,4-dichloro-5-fluorobenzoic acid, and 4-fluorobenzoic acid 2 to give 7-substituted-3-arylmethyl-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-ones 3. Phosphorous oxychloride was used as cyclizing agent. All the newly synthesized compounds 3a-l was screened for their antibacterial activities. Most of them showed promising activity in the range of 10 μg/mL concentrations.

Original languageEnglish
Pages (from-to)2193-2199
Number of pages7
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Issue number10
Publication statusPublished - 10-2003


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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