Synthesis, Pharmacological Evaluation and QSAR Studies of 4,5-Dihydro-4-[(substituted Phenyl) Methylene]-5-oxo-2-Phenyl/methyl-1H-Imidazole-1-Acetic Acids

K. Bharathi, K.V.S.R.G. Prasad, M.N.A. Rao

Research output: Contribution to journalArticle

Abstract

A series of (Z)-4,5-dihydro-4-[(substituted phenyl)methylene]-5-oxo-2-phenyl-1H-imidazole-1-acetic acids (1-11) and a few of (Z)-4,5-dihydro-4-[(substituted phenyl)methylene]-2-methyl-5-oxo-1H-imidazole-1-acetic acids (12-14) were synthesized and evaluated for antiinflammatory activity. Ten compounds showed significant antiinflammatory activity. Compound 2 exhibited activity comparable to phenylbutazone. It also showed significant antiarthritic activity and was less ulcerogenic than phenylbutazone. Five compounds exhibited significant analgesic activity. Several compounds showed good activity in scavenging the stable free radical DPPH. QSAR studies suggested that none of the physicochemical parameters studied showed good correlation to the antiinflammatory activity.
Original languageUndefined/Unknown
Pages (from-to)186-189
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume61
Issue number3
Publication statusPublished - 1999

Cite this

@article{2e72628889aa4e1c9cdb2e3ef2be8489,
title = "Synthesis, Pharmacological Evaluation and QSAR Studies of 4,5-Dihydro-4-[(substituted Phenyl) Methylene]-5-oxo-2-Phenyl/methyl-1H-Imidazole-1-Acetic Acids",
abstract = "A series of (Z)-4,5-dihydro-4-[(substituted phenyl)methylene]-5-oxo-2-phenyl-1H-imidazole-1-acetic acids (1-11) and a few of (Z)-4,5-dihydro-4-[(substituted phenyl)methylene]-2-methyl-5-oxo-1H-imidazole-1-acetic acids (12-14) were synthesized and evaluated for antiinflammatory activity. Ten compounds showed significant antiinflammatory activity. Compound 2 exhibited activity comparable to phenylbutazone. It also showed significant antiarthritic activity and was less ulcerogenic than phenylbutazone. Five compounds exhibited significant analgesic activity. Several compounds showed good activity in scavenging the stable free radical DPPH. QSAR studies suggested that none of the physicochemical parameters studied showed good correlation to the antiinflammatory activity.",
author = "K. Bharathi and K.V.S.R.G. Prasad and M.N.A. Rao",
note = "cited By 0",
year = "1999",
language = "Undefined/Unknown",
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pages = "186--189",
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Synthesis, Pharmacological Evaluation and QSAR Studies of 4,5-Dihydro-4-[(substituted Phenyl) Methylene]-5-oxo-2-Phenyl/methyl-1H-Imidazole-1-Acetic Acids. / Bharathi, K.; Prasad, K.V.S.R.G.; Rao, M.N.A.

In: Indian Journal of Pharmaceutical Sciences, Vol. 61, No. 3, 1999, p. 186-189.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis, Pharmacological Evaluation and QSAR Studies of 4,5-Dihydro-4-[(substituted Phenyl) Methylene]-5-oxo-2-Phenyl/methyl-1H-Imidazole-1-Acetic Acids

AU - Bharathi, K.

AU - Prasad, K.V.S.R.G.

AU - Rao, M.N.A.

N1 - cited By 0

PY - 1999

Y1 - 1999

N2 - A series of (Z)-4,5-dihydro-4-[(substituted phenyl)methylene]-5-oxo-2-phenyl-1H-imidazole-1-acetic acids (1-11) and a few of (Z)-4,5-dihydro-4-[(substituted phenyl)methylene]-2-methyl-5-oxo-1H-imidazole-1-acetic acids (12-14) were synthesized and evaluated for antiinflammatory activity. Ten compounds showed significant antiinflammatory activity. Compound 2 exhibited activity comparable to phenylbutazone. It also showed significant antiarthritic activity and was less ulcerogenic than phenylbutazone. Five compounds exhibited significant analgesic activity. Several compounds showed good activity in scavenging the stable free radical DPPH. QSAR studies suggested that none of the physicochemical parameters studied showed good correlation to the antiinflammatory activity.

AB - A series of (Z)-4,5-dihydro-4-[(substituted phenyl)methylene]-5-oxo-2-phenyl-1H-imidazole-1-acetic acids (1-11) and a few of (Z)-4,5-dihydro-4-[(substituted phenyl)methylene]-2-methyl-5-oxo-1H-imidazole-1-acetic acids (12-14) were synthesized and evaluated for antiinflammatory activity. Ten compounds showed significant antiinflammatory activity. Compound 2 exhibited activity comparable to phenylbutazone. It also showed significant antiarthritic activity and was less ulcerogenic than phenylbutazone. Five compounds exhibited significant analgesic activity. Several compounds showed good activity in scavenging the stable free radical DPPH. QSAR studies suggested that none of the physicochemical parameters studied showed good correlation to the antiinflammatory activity.

M3 - Article

VL - 61

SP - 186

EP - 189

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 3

ER -