Synthesis, structure, electrochemistry and spectral characterization of (d-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich Ascites Carcinoma in Swiss albino mice

M.P. Sathisha, S. Budagumpi, N.V. Kulkarni, G.S. Kurdekar, V.K. Revankar, K.S.R. Pai

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The novel glycosyl saccharide derivative, (d-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic effects. The copper complex, [CuLCl] inhibited Ehrlich Ascites Carcinoma (EAC) induced cancer cell lines in Swiss albino mice at LC50 = 1.94 × 10-8 (LC50 = 2.76 × 10-8 for cisplatin) and so distinctly better than free ligand and other complexes. © 2009 Elsevier Masson SAS.
Original languageEnglish
Pages (from-to)106-113
Number of pages8
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number1
DOIs
Publication statusPublished - 2010

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