The novel glycosyl saccharide derivative, (d-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic effects. The copper complex, [CuLCl] inhibited Ehrlich Ascites Carcinoma (EAC) induced cancer cell lines in Swiss albino mice at LC50 = 1.94 × 10-8 (LC50 = 2.76 × 10-8 for cisplatin) and so distinctly better than free ligand and other complexes. © 2009 Elsevier Masson SAS.
Sathisha, M. P., Budagumpi, S., Kulkarni, N. V., Kurdekar, G. S., Revankar, V. K., & Pai, K. S. R. (2010). Synthesis, structure, electrochemistry and spectral characterization of (d-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich Ascites Carcinoma in Swiss albino mice. European Journal of Medicinal Chemistry, 45(1), 106-113. https://doi.org/10.1016/j.ejmech.2009.09.031