Systematic mastocytosis: Predominantly involving the bone, a case report

Ketan P. Mallya, Sushma Belurkar, Annamm A. Kurian, Laxmi Rao, Bikash Singhania

Research output: Contribution to journalArticle

Abstract

Systemic mastocytosis (SM) is a rare clonal disorder of mast cells that can range from chronic smouldering type to aggressive mast cell leukaemia. It presents with non-specific symptoms like urticaria pigmentosa, unexplained flushing, hypotension and abdominal cramps, which may lead to a misdiagnosis, if there is no high index of clinical suspicion. This is a case report of a 52-year-old lady, with systemic mastocytosis, who presented with severe chronic back ache and no other clinical features. X - ray revealed lytic lesions in the lumbar vertebrae and bone marrow aspiration and a trephine biopsy examination showed infiltration by mast cells, with a positivity for Toluidine blue stain and CD 117. She was also noted to have peripheral eosinophilia, which is frequently encountered with this condition. She was diagnosed to have chronic indolent systemic mastocytosis which involved the bone predominantly.

Original languageEnglish
Pages (from-to)2276-2277
Number of pages2
JournalJournal of Clinical and Diagnostic Research
Volume7
Issue number10
DOIs
Publication statusPublished - 05-10-2013

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Systemic Mastocytosis
Mastocytosis
Bone
Bone and Bones
Mast Cells
Tolonium Chloride
Biopsy
Mast-Cell Leukemia
Urticaria Pigmentosa
Infiltration
Lumbar Vertebrae
Coloring Agents
Colic
Eosinophilia
Back Pain
Diagnostic Errors
X rays
Hypotension
Bone Marrow
X-Rays

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Mallya, Ketan P. ; Belurkar, Sushma ; Kurian, Annamm A. ; Rao, Laxmi ; Singhania, Bikash. / Systematic mastocytosis : Predominantly involving the bone, a case report. In: Journal of Clinical and Diagnostic Research. 2013 ; Vol. 7, No. 10. pp. 2276-2277.
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Systematic mastocytosis : Predominantly involving the bone, a case report. / Mallya, Ketan P.; Belurkar, Sushma; Kurian, Annamm A.; Rao, Laxmi; Singhania, Bikash.

In: Journal of Clinical and Diagnostic Research, Vol. 7, No. 10, 05.10.2013, p. 2276-2277.

Research output: Contribution to journalArticle

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