Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes

A preliminary study

Ganesh Chandra Jagetia, Manjeshwar Shrinath Baliga

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The effects of various concentrations (0.0, 1.56, 3.125, 6.25, 12.5, 25, 50 and 100 μg/ml) of the leaf extract of Syzygium cumini Linn. or Eugenia cumini (SC; black plum, Jamun, family Myrtaceae) was studied on the alteration in the radiation-induced micronuclei formation in the cultured human peripheral blood lymphocytes. Treatment of lymphocytes to various concentrations of SC resulted in a dose dependent increase in the micronuclei-induction, especially after 25-100 μg/ml extract. The exposure of human lymphocytes to various concentrations of SC extract before 3 Gy γ-irradiation resulted in a significant decline in the micronuclei-induction at all the drug doses when compared with the non-drug treated irradiated cultures. A nadir in MNBNC frequency was observed for 12.5 μg/ml drug concentration, where the MNBNC frequency was approximately fourfold lower than that of the non-drug treated irradiated cultures. Therefore, this dose may be considered as an optimum dose for radiation protection. Our study demonstrates that the leaf extract of S. cumini, a plant traditionally used to treat diabetic disorders protects against the radiation-induced DNA damage.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalToxicology Letters
Volume132
Issue number1
DOIs
Publication statusPublished - 07-06-2002
Externally publishedYes

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Syzygium
Lymphocytes
DNA Damage
Blood
Radiation
DNA
Myrtaceae
Radiation protection
Radiation Protection
Pharmaceutical Preparations
Dosimetry
Irradiation

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

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Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes : A preliminary study. / Jagetia, Ganesh Chandra; Baliga, Manjeshwar Shrinath.

In: Toxicology Letters, Vol. 132, No. 1, 07.06.2002, p. 19-25.

Research output: Contribution to journalArticle

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