T3P mediated synthesis of some new quinoline substituted pyrazole derivatives and its antibacterial studies

B. Chandrakantha, Arun M. Isloor, S. K. Peethambar, Prakash Shetty

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A series of new N-(substituted)-5-phenyl-1-(quinolin-2-yl)-1H-pyrazole-4-carboxamide derivatives (5a-h) have been synthesized by condensing ethyl-3-(dimethylamino)-2-[(phenyl)carbonyl]prop-2-enoate 2 with quinoline-2-yl-hydrazine. Compound 3 is hydrolyzed into 4 which is upon further coupled with different aromatic/aliphatic amines using 50% prpopyl phosphonic anhydride (T3P) in ethyl acetate as coupling reagent to afford different quinoline substituted pyrazole carboxamide derivatives. All the newly synthesized compounds were screened for their invitro antibacterial studies against Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa. The results revealed that compounds 5d, 5f, and 5h showed good antibacterial activity towards all bacterial strains. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses.

Original languageEnglish
Pages (from-to)1723-1729
Number of pages7
JournalDer Pharma Chemica
Volume4
Issue number4
Publication statusPublished - 12-12-2012

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hydrazine
Derivatives
Anhydrides
Bacilli
Escherichia coli
Amines
Nuclear magnetic resonance
pyrazole
quinoline
ethyl acetate

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Chandrakantha, B. ; Isloor, Arun M. ; Peethambar, S. K. ; Shetty, Prakash. / T3P mediated synthesis of some new quinoline substituted pyrazole derivatives and its antibacterial studies. In: Der Pharma Chemica. 2012 ; Vol. 4, No. 4. pp. 1723-1729.
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T3P mediated synthesis of some new quinoline substituted pyrazole derivatives and its antibacterial studies. / Chandrakantha, B.; Isloor, Arun M.; Peethambar, S. K.; Shetty, Prakash.

In: Der Pharma Chemica, Vol. 4, No. 4, 12.12.2012, p. 1723-1729.

Research output: Contribution to journalArticle

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