Targeting oncogenic transcription factors by polyphenols

A novel approach for cancer therapy

Chitra Rajagopal, Manendra Babu Lankadasari, Jesil Mathew Aranjani, K. B. Harikumar

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Inflammation is one of the major causative factor of cancer and chronic inflammation is involved in all the major steps of cancer initiation, progression metastasis and drug resistance. The molecular mechanism of inflammation driven cancer is the complex interplay between oncogenic and tumor suppressive transcription factors which include FOXM1, NF-kB, STAT3, Wnt/β- Catenin, HIF-1α NRF2, androgen and estrogen receptors. Several products derived from natural sources modulate the expression and activity of multiple transcription factors in various tumor models as evident from studies conducted in cell lines, pre-clinical models and clinical samples. Further combination of these natural products along with currently approved cancer therapies added an additional advantage and they considered as promising targets for prevention and treatment of inflammation and cancer. In this review we discuss the application of multi-targeting natural products by analyzing the literature and future directions for their plausible applications in drug discovery.

Original languageEnglish
Pages (from-to)273-291
Number of pages19
JournalPharmacological Research
Volume130
DOIs
Publication statusPublished - 01-04-2018

Fingerprint

Polyphenols
Transcription Factors
Neoplasms
Inflammation
Biological Products
Therapeutics
Catenins
NF-kappa B
Androgen Receptors
Drug Discovery
Drug Resistance
Estrogen Receptors
Neoplasm Metastasis
Cell Line

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Rajagopal, Chitra ; Lankadasari, Manendra Babu ; Aranjani, Jesil Mathew ; Harikumar, K. B. / Targeting oncogenic transcription factors by polyphenols : A novel approach for cancer therapy. In: Pharmacological Research. 2018 ; Vol. 130. pp. 273-291.
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Targeting oncogenic transcription factors by polyphenols : A novel approach for cancer therapy. / Rajagopal, Chitra; Lankadasari, Manendra Babu; Aranjani, Jesil Mathew; Harikumar, K. B.

In: Pharmacological Research, Vol. 130, 01.04.2018, p. 273-291.

Research output: Contribution to journalReview article

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