TB iris

A clinical outcome among HIV patients receiving antiretroviral therapy in a tuberculosis prevelant area

Yadlapati Sujani, Achappa Basavaprabhu, Bajpai Sukrit, Mahalingam Soundarya, Jain Simran

Research output: Contribution to journalArticle

Abstract

Introduction: IRIS remains as a major obstacle in effective administration of antiretroviral therapy. This study primarily focuses on evaluating the frequency of occurrence of TB-IRIS among HIV patients on antiretroviral therapy. Secondly, it focuses on establishing risk factors or predictors in patients developing TB-IRIS and finally this study aims to determine the various clinical outcomes and effect of IRIS development on survival rates among these patient. Materials & Method: This study is retrospective hospital based executed in the ART centre in Mangalore, Karnataka. Diagnosis of TB-IRIS was made as per INSHI consensus case definition provided for resource-limited settings. The Data from January 2008 till September 2012 was evaluated via semi-structured questionnaire. Inclusion Criteria Patients eligible to receive ART and were above the age of 18. Those patients who were non-compliant with treatment or HIV patients no ton ART were excluded from our sample population Results: A total of 125 patients were included in this study. 37(29.6%) had diagnosed TB before starting the treatment. 6(16.2%) out of the 37 HIV with combined TB patients progressed to paradoxical TB-IRIS when ART drugs were initiated. 88(70.4%) patients did not have active TB when ART was started, among whom 6 patients developed “unmasking” TB-IRIS. 8 (66.7%) out of the 12 patients developed IRIS in a period of three months of initiation of ART rest 4 (33.3%) patients developed after the three month period. 10 (83.33%)out of the 12 patients were male. 5 out of the 6 patients with paradoxical TB-IRIS had extrapulmonary TB at the time of ART initiation. Conclusion: Consensus case definition for the resource limited setting is an effective tool in the diagnosis of TB-IRIS. TB-IRIS can be treated conservatively and although not fatal early diagnosis and management can prevent a complicated course of disease.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalIndian Journal of Public Health Research and Development
Volume9
Issue number11
DOIs
Publication statusPublished - 01-11-2018

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Iris
Tuberculosis
HIV
Therapeutics
Early Diagnosis
Survival Rate
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

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title = "TB iris: A clinical outcome among HIV patients receiving antiretroviral therapy in a tuberculosis prevelant area",
abstract = "Introduction: IRIS remains as a major obstacle in effective administration of antiretroviral therapy. This study primarily focuses on evaluating the frequency of occurrence of TB-IRIS among HIV patients on antiretroviral therapy. Secondly, it focuses on establishing risk factors or predictors in patients developing TB-IRIS and finally this study aims to determine the various clinical outcomes and effect of IRIS development on survival rates among these patient. Materials & Method: This study is retrospective hospital based executed in the ART centre in Mangalore, Karnataka. Diagnosis of TB-IRIS was made as per INSHI consensus case definition provided for resource-limited settings. The Data from January 2008 till September 2012 was evaluated via semi-structured questionnaire. Inclusion Criteria Patients eligible to receive ART and were above the age of 18. Those patients who were non-compliant with treatment or HIV patients no ton ART were excluded from our sample population Results: A total of 125 patients were included in this study. 37(29.6{\%}) had diagnosed TB before starting the treatment. 6(16.2{\%}) out of the 37 HIV with combined TB patients progressed to paradoxical TB-IRIS when ART drugs were initiated. 88(70.4{\%}) patients did not have active TB when ART was started, among whom 6 patients developed “unmasking” TB-IRIS. 8 (66.7{\%}) out of the 12 patients developed IRIS in a period of three months of initiation of ART rest 4 (33.3{\%}) patients developed after the three month period. 10 (83.33{\%})out of the 12 patients were male. 5 out of the 6 patients with paradoxical TB-IRIS had extrapulmonary TB at the time of ART initiation. Conclusion: Consensus case definition for the resource limited setting is an effective tool in the diagnosis of TB-IRIS. TB-IRIS can be treated conservatively and although not fatal early diagnosis and management can prevent a complicated course of disease.",
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TB iris : A clinical outcome among HIV patients receiving antiretroviral therapy in a tuberculosis prevelant area. / Sujani, Yadlapati; Basavaprabhu, Achappa; Sukrit, Bajpai; Soundarya, Mahalingam; Simran, Jain.

In: Indian Journal of Public Health Research and Development, Vol. 9, No. 11, 01.11.2018, p. 225-229.

Research output: Contribution to journalArticle

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