The ameliorative effect of ascorbic acid and Ginkgo biloba on learning and memory deficits associated with fluoride exposure

Jetti Raghu, Vasudeva C. Raghuveer, Mallikarjuna C. Rao, Nagabhooshana S. Somayaji, Prakash B. Babu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chronic exposure to fluoride causes dental and skeletal fluorosis. Fluoride exposure is also detrimental to soft tissues and organs. The present study aimed at evaluation of the effect of Ginkgo biloba and ascorbic acid on learning and memory deficits caused by fluoride exposure. Male Wistar rats were divided into five groups (n=6). Group 1 control. Groups 2 to 5 received 100 ppm of sodium fluoride over 30 days. Groups 3, 4 and 5 were further treated for 15 days receiving respectively 1% gum acacia solution, 100 mg/kg body weight ascorbic acid, and 100mg/kg body weight Ginkgo biloba extract. After 45 days, all animals were subjected to behavioural tests. The results showed that fluoride affected learning and memory. Fluoride causes oxidative stress and neurodegeneration, thereby affecting learning and memory. Ascorbic acid and Ginkgo biloba were found to augment the reversal of learning and memory deficits caused by fluoride ingestion.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalInterdisciplinary Toxicology
Volume6
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

Ginkgo biloba
Memory Disorders
Fluorides
Ascorbic Acid
Learning
Data storage equipment
Body Weight
Dental Fluorosis
Reversal Learning
Gum Arabic
Sodium Fluoride
Oxidative stress
Wistar Rats
Rats
Animals
Oxidative Stress
Eating
Tissue
Control Groups

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

Cite this

Raghu, Jetti ; Raghuveer, Vasudeva C. ; Rao, Mallikarjuna C. ; Somayaji, Nagabhooshana S. ; Babu, Prakash B. / The ameliorative effect of ascorbic acid and Ginkgo biloba on learning and memory deficits associated with fluoride exposure. In: Interdisciplinary Toxicology. 2013 ; Vol. 6, No. 4. pp. 217-221.
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The ameliorative effect of ascorbic acid and Ginkgo biloba on learning and memory deficits associated with fluoride exposure. / Raghu, Jetti; Raghuveer, Vasudeva C.; Rao, Mallikarjuna C.; Somayaji, Nagabhooshana S.; Babu, Prakash B.

In: Interdisciplinary Toxicology, Vol. 6, No. 4, 2013, p. 217-221.

Research output: Contribution to journalArticle

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