The effect of gabapentin and phenytoin on sperm-morphology in Wistar rats.

Akhila J. Shetty

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5 Citations (Scopus)

Abstract

The objective of the present study was to investigate the effects of the antiepileptic drugs, gabapentin and phenytoin, on sperm morphology in Wistar rats. Groups (n=5) of rats were treated with cyclophosphamide (20 mg/day), gabapentin (16, 25, 32 mg/day) and phenytoin (3.5, 5.5, 7 mg/day) for five consecutive days. 14 and 35 days after the last exposure, sperm morphology was evaluated by standard procedure. Gabapentin and phenytoin did not induce significant changes in sperm morphology. The results suggest that phenytoin and gabapentin are not germ cell mutagens in males, and do not appear to adversely affect male fertility.

Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalReproductive biology
Volume7
Issue number3
Publication statusPublished - 01-11-2007
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • Endocrinology
  • Developmental Biology

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