The effect of N-methyl-N-nitrosourea (MNU) and dimethylbenzanthracene (DMBA) in developing the mammary tumor in Wistar albino and Sprague dawley rats-A comparative study

Maninder Kour, N. A. Vinodini, Kumar M.R. Bhat, Shrijeet Chakraborti, A. K. Nayanatara

Research output: Contribution to journalArticle

Abstract

The existing methods for the induction of tumor in mammary cancer research using animal models are lengthy, perilous, and sometimes irreproducible and not convenient. Therefore, objective of the study was to find out, a most effective less time consuming model to produce mammary tumor in animal mode. We used two different strains of animals and two carcinogens MNU and DMBA in different concentrations to induce mammary tumor. In this study we found that Sprague Dawley rats developed malignant mammary tumor within two months of time compared to the Wistar strain and size of the tumor increased exponentially. Histopathological examination revealed that the tumors which were induced were showing adenocarcinomas of mammary gland. Therefore, this study suggests that Sprague dawley rats and MNU as carcinogen is the better animal model for tumor induction having least tumor latency and maximum tumor incidence in breast cancer research compared to Wistar albino rats.

Original languageEnglish
Pages (from-to)1758-1762
Number of pages5
JournalAdvanced Science Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 01-03-2017

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Methylnitrosourea
tumor
Comparative Study
Sprague Dawley Rats
Rats
Tumors
Tumor
comparative study
animal
Breast Neoplasms
induction
Neoplasms
cancer
Animals
Carcinogens
Animal Model
Animal Models
carcinogen
incidence
Proof by induction

All Science Journal Classification (ASJC) codes

  • Computer Science(all)
  • Health(social science)
  • Mathematics(all)
  • Education
  • Environmental Science(all)
  • Engineering(all)
  • Energy(all)

Cite this

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abstract = "The existing methods for the induction of tumor in mammary cancer research using animal models are lengthy, perilous, and sometimes irreproducible and not convenient. Therefore, objective of the study was to find out, a most effective less time consuming model to produce mammary tumor in animal mode. We used two different strains of animals and two carcinogens MNU and DMBA in different concentrations to induce mammary tumor. In this study we found that Sprague Dawley rats developed malignant mammary tumor within two months of time compared to the Wistar strain and size of the tumor increased exponentially. Histopathological examination revealed that the tumors which were induced were showing adenocarcinomas of mammary gland. Therefore, this study suggests that Sprague dawley rats and MNU as carcinogen is the better animal model for tumor induction having least tumor latency and maximum tumor incidence in breast cancer research compared to Wistar albino rats.",
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AU - Chakraborti, Shrijeet

AU - Nayanatara, A. K.

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AB - The existing methods for the induction of tumor in mammary cancer research using animal models are lengthy, perilous, and sometimes irreproducible and not convenient. Therefore, objective of the study was to find out, a most effective less time consuming model to produce mammary tumor in animal mode. We used two different strains of animals and two carcinogens MNU and DMBA in different concentrations to induce mammary tumor. In this study we found that Sprague Dawley rats developed malignant mammary tumor within two months of time compared to the Wistar strain and size of the tumor increased exponentially. Histopathological examination revealed that the tumors which were induced were showing adenocarcinomas of mammary gland. Therefore, this study suggests that Sprague dawley rats and MNU as carcinogen is the better animal model for tumor induction having least tumor latency and maximum tumor incidence in breast cancer research compared to Wistar albino rats.

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