The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats

P. Vijay, R. Yeshwanth, K. Bairy

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7 Citations (Scopus)


Objective: To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats. Methods: Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2nd, 4th, 5th, 7th, 10thand 15thweek, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis. Results: The intratesticular testosterone level was significantly (P< 0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P< 0.001) increased by valproate in a time dependent manner. Conclusion: Valproate causes reversible change in intratesticular testosterone and LDH level.

Original languageEnglish
Pages (from-to)248-250
Number of pages3
JournalIndian Journal of Pharmacology
Issue number6
Publication statusPublished - 01-11-2008
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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