The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats

P. Vijay, R. Yeshwanth, K. Bairy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats. Methods: Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2nd, 4th, 5th, 7th, 10thand 15thweek, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis. Results: The intratesticular testosterone level was significantly (P< 0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P< 0.001) increased by valproate in a time dependent manner. Conclusion: Valproate causes reversible change in intratesticular testosterone and LDH level.

Original languageEnglish
Pages (from-to)248-250
Number of pages3
JournalIndian Journal of Pharmacology
Volume40
Issue number6
DOIs
Publication statusPublished - 01-11-2008
Externally publishedYes

Fingerprint

Valproic Acid
Wistar Rats
L-Lactate Dehydrogenase
Testosterone
17-Hydroxysteroid Dehydrogenases
Testis
Milk

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

@article{8e0fce9a6f9f4639a39dacd35a08f6af,
title = "The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats",
abstract = "Objective: To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats. Methods: Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2nd, 4th, 5th, 7th, 10thand 15thweek, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis. Results: The intratesticular testosterone level was significantly (P< 0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P< 0.001) increased by valproate in a time dependent manner. Conclusion: Valproate causes reversible change in intratesticular testosterone and LDH level.",
author = "P. Vijay and R. Yeshwanth and K. Bairy",
year = "2008",
month = "11",
day = "1",
doi = "10.4103/0253-7613.45149",
language = "English",
volume = "40",
pages = "248--250",
journal = "Indian Journal of Pharmacology",
issn = "0253-7613",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "6",

}

The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats. / Vijay, P.; Yeshwanth, R.; Bairy, K.

In: Indian Journal of Pharmacology, Vol. 40, No. 6, 01.11.2008, p. 248-250.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats

AU - Vijay, P.

AU - Yeshwanth, R.

AU - Bairy, K.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Objective: To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats. Methods: Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2nd, 4th, 5th, 7th, 10thand 15thweek, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis. Results: The intratesticular testosterone level was significantly (P< 0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P< 0.001) increased by valproate in a time dependent manner. Conclusion: Valproate causes reversible change in intratesticular testosterone and LDH level.

AB - Objective: To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats. Methods: Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2nd, 4th, 5th, 7th, 10thand 15thweek, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis. Results: The intratesticular testosterone level was significantly (P< 0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P< 0.001) increased by valproate in a time dependent manner. Conclusion: Valproate causes reversible change in intratesticular testosterone and LDH level.

UR - http://www.scopus.com/inward/record.url?scp=58849085504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849085504&partnerID=8YFLogxK

U2 - 10.4103/0253-7613.45149

DO - 10.4103/0253-7613.45149

M3 - Article

AN - SCOPUS:58849085504

VL - 40

SP - 248

EP - 250

JO - Indian Journal of Pharmacology

JF - Indian Journal of Pharmacology

SN - 0253-7613

IS - 6

ER -