The effect of tranexamic acid on hemoglobin levels during total knee arthroplasty

Amit Pachauri, Kiran K. Acharya, Akhilesh Kumar Tiwari

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of this study was to evaluate the efficacy of perioperative administration of 1,4-aminocarboxylic acid (tranexamic acid) in reducing the intraoperative and postoperative blood loss in patients undergoing total knee replacement (TKR). Tranexamic acid is an antifibrinolytic agent that is 7-10 times as potent as epsilon aminocaproic acid. We had investigated the effect of tranexamic acid on blood loss intraoperatively and postoperatively during and after TKR thereby significantly preventing a decrease in postop Hb in these patients. This study was a randomized, prospective, observational, double-blinded study on 99 patients, after obtaining ethical committee approval and valid informed consent from patients to be part of the study. In the study group, the drug was administered in 2 doses 1 hour preoperatively and 6 hours postoperatively. The use of tranexamic acid injection in TKR surgeries can be considered as an effective method to control and minimize the blood loss during total knee arthroplasty surgeries.

Original languageEnglish
Pages (from-to)366-370
Number of pages5
JournalAmerican Journal of Therapeutics
Volume21
Issue number5
Publication statusPublished - 01-01-2014

Fingerprint

Tranexamic Acid
Knee Replacement Arthroplasties
Hemoglobins
Aminocaproic Acid
Postoperative Hemorrhage
Antifibrinolytic Agents
Informed Consent
Injections
Acids
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Medicine(all)

Cite this

@article{8b53b1df7c204af5b449b7f348615381,
title = "The effect of tranexamic acid on hemoglobin levels during total knee arthroplasty",
abstract = "The aim of this study was to evaluate the efficacy of perioperative administration of 1,4-aminocarboxylic acid (tranexamic acid) in reducing the intraoperative and postoperative blood loss in patients undergoing total knee replacement (TKR). Tranexamic acid is an antifibrinolytic agent that is 7-10 times as potent as epsilon aminocaproic acid. We had investigated the effect of tranexamic acid on blood loss intraoperatively and postoperatively during and after TKR thereby significantly preventing a decrease in postop Hb in these patients. This study was a randomized, prospective, observational, double-blinded study on 99 patients, after obtaining ethical committee approval and valid informed consent from patients to be part of the study. In the study group, the drug was administered in 2 doses 1 hour preoperatively and 6 hours postoperatively. The use of tranexamic acid injection in TKR surgeries can be considered as an effective method to control and minimize the blood loss during total knee arthroplasty surgeries.",
author = "Amit Pachauri and Acharya, {Kiran K.} and Tiwari, {Akhilesh Kumar}",
year = "2014",
month = "1",
day = "1",
language = "English",
volume = "21",
pages = "366--370",
journal = "American Journal of Therapeutics",
issn = "1075-2765",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

The effect of tranexamic acid on hemoglobin levels during total knee arthroplasty. / Pachauri, Amit; Acharya, Kiran K.; Tiwari, Akhilesh Kumar.

In: American Journal of Therapeutics, Vol. 21, No. 5, 01.01.2014, p. 366-370.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of tranexamic acid on hemoglobin levels during total knee arthroplasty

AU - Pachauri, Amit

AU - Acharya, Kiran K.

AU - Tiwari, Akhilesh Kumar

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The aim of this study was to evaluate the efficacy of perioperative administration of 1,4-aminocarboxylic acid (tranexamic acid) in reducing the intraoperative and postoperative blood loss in patients undergoing total knee replacement (TKR). Tranexamic acid is an antifibrinolytic agent that is 7-10 times as potent as epsilon aminocaproic acid. We had investigated the effect of tranexamic acid on blood loss intraoperatively and postoperatively during and after TKR thereby significantly preventing a decrease in postop Hb in these patients. This study was a randomized, prospective, observational, double-blinded study on 99 patients, after obtaining ethical committee approval and valid informed consent from patients to be part of the study. In the study group, the drug was administered in 2 doses 1 hour preoperatively and 6 hours postoperatively. The use of tranexamic acid injection in TKR surgeries can be considered as an effective method to control and minimize the blood loss during total knee arthroplasty surgeries.

AB - The aim of this study was to evaluate the efficacy of perioperative administration of 1,4-aminocarboxylic acid (tranexamic acid) in reducing the intraoperative and postoperative blood loss in patients undergoing total knee replacement (TKR). Tranexamic acid is an antifibrinolytic agent that is 7-10 times as potent as epsilon aminocaproic acid. We had investigated the effect of tranexamic acid on blood loss intraoperatively and postoperatively during and after TKR thereby significantly preventing a decrease in postop Hb in these patients. This study was a randomized, prospective, observational, double-blinded study on 99 patients, after obtaining ethical committee approval and valid informed consent from patients to be part of the study. In the study group, the drug was administered in 2 doses 1 hour preoperatively and 6 hours postoperatively. The use of tranexamic acid injection in TKR surgeries can be considered as an effective method to control and minimize the blood loss during total knee arthroplasty surgeries.

UR - http://www.scopus.com/inward/record.url?scp=84913529667&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84913529667&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 366

EP - 370

JO - American Journal of Therapeutics

JF - American Journal of Therapeutics

SN - 1075-2765

IS - 5

ER -