The effect of using combination chemotherapy in colorectal cancer in India

A single institute survey

Adiga Sachidananda, K. Meena Kumari, K. L. Bairy, Babu A. Mohan, B. Vadiraja, M. S. Vidyasagar

Research output: Contribution to journalArticle

Abstract

The incidence of colorectal cancer in India is on upward swing due to the change in dietary habits. This study was done to evaluate the efficacy and toxicity of 5-fluorouracil monotherapy and 5-fluorouracil +levamisole regimens. In this study, colorectal cancer patients treated with adjuvant chemotherapy from 1997 to 2001 were included and followed up for a period of five years. The efficacy of the commonly used regimens was compared in terms of five year disease free survival. The various toxicity seen during the adjuvant chemotherapy administration was recorded in either group. The three and five year disease free survivals of 5-fluorouracil monotherapy regimen were 42% and 32% respectively in stage B. The 5-fluorouracil +levamisole regimen had a disease free survival of 46% and 38% in stage B at three and five years respectively. In stage C, the disease free survival at three and five year were 22% and 10% in 5-fluorouracil treated group whereas it was 24% and 16% in 5-fluorouracil with levamisole treated group at similar time interval. The incidence blood dyscrasia and abnormal liver function test were higher in 5-fluorouracil monotherapy group. We conclude that 5-fluorouracil monotherapy had equal disease free survival and slightly more toxic compared to 5-fluorouracil and levamisole combination in stage B & stage C colorectal cancer.

Original languageEnglish
Pages (from-to)518-529
Number of pages12
JournalPharmacologyonline
Volume1
Publication statusPublished - 11-06-2010

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Combination Drug Therapy
Fluorouracil
India
Colorectal Neoplasms
Levamisole
Disease-Free Survival
Adjuvant Chemotherapy
Surveys and Questionnaires
Poisons
Liver Function Tests
Incidence
Feeding Behavior

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

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title = "The effect of using combination chemotherapy in colorectal cancer in India: A single institute survey",
abstract = "The incidence of colorectal cancer in India is on upward swing due to the change in dietary habits. This study was done to evaluate the efficacy and toxicity of 5-fluorouracil monotherapy and 5-fluorouracil +levamisole regimens. In this study, colorectal cancer patients treated with adjuvant chemotherapy from 1997 to 2001 were included and followed up for a period of five years. The efficacy of the commonly used regimens was compared in terms of five year disease free survival. The various toxicity seen during the adjuvant chemotherapy administration was recorded in either group. The three and five year disease free survivals of 5-fluorouracil monotherapy regimen were 42{\%} and 32{\%} respectively in stage B. The 5-fluorouracil +levamisole regimen had a disease free survival of 46{\%} and 38{\%} in stage B at three and five years respectively. In stage C, the disease free survival at three and five year were 22{\%} and 10{\%} in 5-fluorouracil treated group whereas it was 24{\%} and 16{\%} in 5-fluorouracil with levamisole treated group at similar time interval. The incidence blood dyscrasia and abnormal liver function test were higher in 5-fluorouracil monotherapy group. We conclude that 5-fluorouracil monotherapy had equal disease free survival and slightly more toxic compared to 5-fluorouracil and levamisole combination in stage B & stage C colorectal cancer.",
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The effect of using combination chemotherapy in colorectal cancer in India : A single institute survey. / Sachidananda, Adiga; Meena Kumari, K.; Bairy, K. L.; Mohan, Babu A.; Vadiraja, B.; Vidyasagar, M. S.

In: Pharmacologyonline, Vol. 1, 11.06.2010, p. 518-529.

Research output: Contribution to journalArticle

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